Tanshinone IIA: a Chinese herbal ingredient for the treatment of atherosclerosis
Tanshinone IIA (Tan IIA) is a fat-soluble compound extracted from Salvia miltiorrhiza, which has a protective effect against atherosclerosis (AS). Tan IIA can inhibit oxidative stress and inflammatory damage of vascular endothelial cells (VECs) and improve endothelial cell dysfunction. Tan IIA also...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1321880/full |
| _version_ | 1797435140157210624 |
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| author | Chunkun Yang Yanguang Mu Shuanghong Li Yang Zhang Xiaoyuan Liu Jun Li |
| author_facet | Chunkun Yang Yanguang Mu Shuanghong Li Yang Zhang Xiaoyuan Liu Jun Li |
| author_sort | Chunkun Yang |
| collection | DOAJ |
| description | Tanshinone IIA (Tan IIA) is a fat-soluble compound extracted from Salvia miltiorrhiza, which has a protective effect against atherosclerosis (AS). Tan IIA can inhibit oxidative stress and inflammatory damage of vascular endothelial cells (VECs) and improve endothelial cell dysfunction. Tan IIA also has a good protective effect on vascular smooth muscle cells (VSMCs). It can reduce vascular stenosis by inhibiting the proliferation and migration of vascular smooth muscle cells (VSMCs), and improve the stability of the fibrous cap of atherosclerotic plaque by inhibiting apoptosis and inflammation of VSMCs. In addition, Tan IIA inhibits the inflammatory response of macrophages and the formation of foam cells in atherosclerotic plaques. In summary, Tan IIA improves AS through a complex pathway. We propose to further study the specific molecular targets of Tan IIA using systems biology methods, so as to fundamentally elucidate the mechanism of Tan IIA. It is worth mentioning that there is a lack of high-quality evidence-based medical data on Tan IIA treatment of AS. We recommend that a randomized controlled clinical trial be conducted to evaluate the exact efficacy of Tan IIA in improving AS. Finally, sodium tanshinone IIA sulfonate (STS) can cause adverse drug reactions in some patients, which needs our attention. |
| first_indexed | 2024-03-09T10:42:55Z |
| format | Article |
| id | doaj.art-cc886abce63347a3ad5904590b0aa675 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-09T10:42:55Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-cc886abce63347a3ad5904590b0aa6752023-12-01T12:39:59ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-12-011410.3389/fphar.2023.13218801321880Tanshinone IIA: a Chinese herbal ingredient for the treatment of atherosclerosisChunkun Yang0Yanguang Mu1Shuanghong Li2Yang Zhang3Xiaoyuan Liu4Jun Li5Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaWeifang People’s Hospital, Weifang, ChinaWeifang Hospital of Traditional Chinese Medicine, Weifang, ChinaWeifang People’s Hospital, Weifang, ChinaWeifang Hospital of Traditional Chinese Medicine, Weifang, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaTanshinone IIA (Tan IIA) is a fat-soluble compound extracted from Salvia miltiorrhiza, which has a protective effect against atherosclerosis (AS). Tan IIA can inhibit oxidative stress and inflammatory damage of vascular endothelial cells (VECs) and improve endothelial cell dysfunction. Tan IIA also has a good protective effect on vascular smooth muscle cells (VSMCs). It can reduce vascular stenosis by inhibiting the proliferation and migration of vascular smooth muscle cells (VSMCs), and improve the stability of the fibrous cap of atherosclerotic plaque by inhibiting apoptosis and inflammation of VSMCs. In addition, Tan IIA inhibits the inflammatory response of macrophages and the formation of foam cells in atherosclerotic plaques. In summary, Tan IIA improves AS through a complex pathway. We propose to further study the specific molecular targets of Tan IIA using systems biology methods, so as to fundamentally elucidate the mechanism of Tan IIA. It is worth mentioning that there is a lack of high-quality evidence-based medical data on Tan IIA treatment of AS. We recommend that a randomized controlled clinical trial be conducted to evaluate the exact efficacy of Tan IIA in improving AS. Finally, sodium tanshinone IIA sulfonate (STS) can cause adverse drug reactions in some patients, which needs our attention.https://www.frontiersin.org/articles/10.3389/fphar.2023.1321880/fulltanshinone IIAvascular endothelial cellsvascular smooth muscle cellsatherosclerosisplaquesadverse drug reactions |
| spellingShingle | Chunkun Yang Yanguang Mu Shuanghong Li Yang Zhang Xiaoyuan Liu Jun Li Tanshinone IIA: a Chinese herbal ingredient for the treatment of atherosclerosis Frontiers in Pharmacology tanshinone IIA vascular endothelial cells vascular smooth muscle cells atherosclerosis plaques adverse drug reactions |
| title | Tanshinone IIA: a Chinese herbal ingredient for the treatment of atherosclerosis |
| title_full | Tanshinone IIA: a Chinese herbal ingredient for the treatment of atherosclerosis |
| title_fullStr | Tanshinone IIA: a Chinese herbal ingredient for the treatment of atherosclerosis |
| title_full_unstemmed | Tanshinone IIA: a Chinese herbal ingredient for the treatment of atherosclerosis |
| title_short | Tanshinone IIA: a Chinese herbal ingredient for the treatment of atherosclerosis |
| title_sort | tanshinone iia a chinese herbal ingredient for the treatment of atherosclerosis |
| topic | tanshinone IIA vascular endothelial cells vascular smooth muscle cells atherosclerosis plaques adverse drug reactions |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1321880/full |
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