The Predictive Significance of Prognostic Nutritional Index and Serum Albumin/Globulin Ratio on the Overall Survival of Penile Cancer Patients Undergoing Penectomy
<b>Objective:</b> To assess the value of using the prognostic nutritional index (PNI) and serum albumin/globulin ratio (AGR) in predicting the overall survival (OS) of patients with penile cancer (PC) undergoing penectomy. <b>Materials and methods:</b> A retrospective analysi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/29/10/596 |
| _version_ | 1827650842064322560 |
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| author | Wei-Jie Song Ni-Chujie Li Jun Gao Zhi-Peng Xu Jian-Ye Liu Zhi Long Le-Ye He |
| author_facet | Wei-Jie Song Ni-Chujie Li Jun Gao Zhi-Peng Xu Jian-Ye Liu Zhi Long Le-Ye He |
| author_sort | Wei-Jie Song |
| collection | DOAJ |
| description | <b>Objective:</b> To assess the value of using the prognostic nutritional index (PNI) and serum albumin/globulin ratio (AGR) in predicting the overall survival (OS) of patients with penile cancer (PC) undergoing penectomy. <b>Materials and methods:</b> A retrospective analysis of 123 patients who were admitted to our hospital due to PC from April 2010 to September 2021 and who underwent penectomy were included in the study. The optimal cut-off value of the PNI and AGR was determined by receiver operating characteristic curve analysis. Kaplan–Meier analysis and the Cox proportional hazard model were used to evaluate the correlation between the PNI, AGR, and OS in patients with PC. <b>Results:</b> A total of 16 of the 123 patients died during the follow-up period, and the median follow-up time was 58.0 months. The best cut-off values of the PNI and AGR were set to 49.03 (95% confidence interval 0.705–0.888, Youden index = 0.517, sensitivity = 57.9%, specificity = 93.7%, <i>p</i> < 0.001) and 1.28 (95% confidence interval 0.610–0.860, Youden index = 0.404, sensitivity = 84.1%, specificity = 56.2%, <i>p</i> = 0.003). The Kaplan–Meier analysis showed that the OS of the patients in the high PNI group and the high AGR group was significantly higher than that of the patients in the low PNI group and the low AGR group (<i>p</i> < 0.001). The univariable analysis showed that the aCCI, the clinical N stage, the pathological stage, and the PNI, AGR, SII, and PLR are all predictors of OS in patients with PC (<i>p</i> < 0.05). The multivariable analysis showed that the PNI (risk rate [HR] = 0.091; 95% CI: 0.010–0.853; <i>p</i> = 0.036) and the AGR (risk rate [HR] = 0.171; 95% CI: 0.043–0.680; <i>p</i> = 0.012) are independent prognostic factors for predicting OS in patients with PC undergoing penectomy. <b>Conclusions:</b> Both the PNI score and the serum AGR are independent prognostic factors for predicting OS in patients with PC undergoing penectomy. |
| first_indexed | 2024-03-09T20:24:38Z |
| format | Article |
| id | doaj.art-cc8ae7d0db88466b981cf666f288136b |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T20:24:38Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-cc8ae7d0db88466b981cf666f288136b2023-11-23T23:40:42ZengMDPI AGCurrent Oncology1198-00521718-77292022-10-0129107569757810.3390/curroncol29100596The Predictive Significance of Prognostic Nutritional Index and Serum Albumin/Globulin Ratio on the Overall Survival of Penile Cancer Patients Undergoing PenectomyWei-Jie Song0Ni-Chujie Li1Jun Gao2Zhi-Peng Xu3Jian-Ye Liu4Zhi Long5Le-Ye He6Department of Urology, Central South University, The Third Xiangya Hospital, Changsha 410013, ChinaDepartment of Urology, Central South University, The Third Xiangya Hospital, Changsha 410013, ChinaDepartment of Urology, Central South University, The Third Xiangya Hospital, Changsha 410013, ChinaDepartment of Urology, Central South University, The Third Xiangya Hospital, Changsha 410013, ChinaDepartment of Urology, Central South University, The Third Xiangya Hospital, Changsha 410013, ChinaDepartment of Urology, Central South University, The Third Xiangya Hospital, Changsha 410013, ChinaDepartment of Urology, Central South University, The Third Xiangya Hospital, Changsha 410013, China<b>Objective:</b> To assess the value of using the prognostic nutritional index (PNI) and serum albumin/globulin ratio (AGR) in predicting the overall survival (OS) of patients with penile cancer (PC) undergoing penectomy. <b>Materials and methods:</b> A retrospective analysis of 123 patients who were admitted to our hospital due to PC from April 2010 to September 2021 and who underwent penectomy were included in the study. The optimal cut-off value of the PNI and AGR was determined by receiver operating characteristic curve analysis. Kaplan–Meier analysis and the Cox proportional hazard model were used to evaluate the correlation between the PNI, AGR, and OS in patients with PC. <b>Results:</b> A total of 16 of the 123 patients died during the follow-up period, and the median follow-up time was 58.0 months. The best cut-off values of the PNI and AGR were set to 49.03 (95% confidence interval 0.705–0.888, Youden index = 0.517, sensitivity = 57.9%, specificity = 93.7%, <i>p</i> < 0.001) and 1.28 (95% confidence interval 0.610–0.860, Youden index = 0.404, sensitivity = 84.1%, specificity = 56.2%, <i>p</i> = 0.003). The Kaplan–Meier analysis showed that the OS of the patients in the high PNI group and the high AGR group was significantly higher than that of the patients in the low PNI group and the low AGR group (<i>p</i> < 0.001). The univariable analysis showed that the aCCI, the clinical N stage, the pathological stage, and the PNI, AGR, SII, and PLR are all predictors of OS in patients with PC (<i>p</i> < 0.05). The multivariable analysis showed that the PNI (risk rate [HR] = 0.091; 95% CI: 0.010–0.853; <i>p</i> = 0.036) and the AGR (risk rate [HR] = 0.171; 95% CI: 0.043–0.680; <i>p</i> = 0.012) are independent prognostic factors for predicting OS in patients with PC undergoing penectomy. <b>Conclusions:</b> Both the PNI score and the serum AGR are independent prognostic factors for predicting OS in patients with PC undergoing penectomy.https://www.mdpi.com/1718-7729/29/10/596prognostic nutritional indexalbumin/globulin ratiopenile cancerpenectomyoverall survivalprognostic factors |
| spellingShingle | Wei-Jie Song Ni-Chujie Li Jun Gao Zhi-Peng Xu Jian-Ye Liu Zhi Long Le-Ye He The Predictive Significance of Prognostic Nutritional Index and Serum Albumin/Globulin Ratio on the Overall Survival of Penile Cancer Patients Undergoing Penectomy Current Oncology prognostic nutritional index albumin/globulin ratio penile cancer penectomy overall survival prognostic factors |
| title | The Predictive Significance of Prognostic Nutritional Index and Serum Albumin/Globulin Ratio on the Overall Survival of Penile Cancer Patients Undergoing Penectomy |
| title_full | The Predictive Significance of Prognostic Nutritional Index and Serum Albumin/Globulin Ratio on the Overall Survival of Penile Cancer Patients Undergoing Penectomy |
| title_fullStr | The Predictive Significance of Prognostic Nutritional Index and Serum Albumin/Globulin Ratio on the Overall Survival of Penile Cancer Patients Undergoing Penectomy |
| title_full_unstemmed | The Predictive Significance of Prognostic Nutritional Index and Serum Albumin/Globulin Ratio on the Overall Survival of Penile Cancer Patients Undergoing Penectomy |
| title_short | The Predictive Significance of Prognostic Nutritional Index and Serum Albumin/Globulin Ratio on the Overall Survival of Penile Cancer Patients Undergoing Penectomy |
| title_sort | predictive significance of prognostic nutritional index and serum albumin globulin ratio on the overall survival of penile cancer patients undergoing penectomy |
| topic | prognostic nutritional index albumin/globulin ratio penile cancer penectomy overall survival prognostic factors |
| url | https://www.mdpi.com/1718-7729/29/10/596 |
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