Artificial Diploid Escherichia coli by a CRISPR Chromosome‐Doubling Technique

Artificial Diploid Escherichia coli by a CRISPR Chromosome‐Doubling Technique

Abstract Synthetic biology has been represented by the creation of artificial life forms at the genomic scale. In this work, a CRISPR‐based chromosome‐doubling technique is designed to first construct an artificial diploid Escherichia coli cell. The stable single‐cell diploid E. coli is isolated by...

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Bibliographic Details
Main Authors: Pengju Wang, Dongdong Zhao, Ju Li, Junchang Su, Chunzhi Zhang, Siwei Li, Feiyu Fan, Zhubo Dai, Xiaoping Liao, Zhitao Mao, Changhao Bi, Xueli Zhang
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Advanced Science
Subjects:
bio‐evolution
CRISPR
polyploidy
synthetic biology
Online Access:https://doi.org/10.1002/advs.202205855

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