The Expression and Clinical Significance of Sphingosine Kinase 1 and Vascular Endothelial Growth Factor in Endometrial Carcinoma
The aim of the study is to investigate the expression of sphingosine kinase 1 (SPHK1) and vascular endothelial growth factor (VEGF) in patients with endometrial carcinoma and its clinical significance. The tissues of 86 cases of patients with endometrial carcinoma and 54 cases of patients with endom...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2022-01-01
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| Series: | Emergency Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2022/6716143 |
| _version_ | 1811181770417111040 |
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| author | Hong Yu null Dejizhuoga Wei Huang Donglian Wang null Gamaquzhen Xiaomin Jia Hao Feng |
| author_facet | Hong Yu null Dejizhuoga Wei Huang Donglian Wang null Gamaquzhen Xiaomin Jia Hao Feng |
| author_sort | Hong Yu |
| collection | DOAJ |
| description | The aim of the study is to investigate the expression of sphingosine kinase 1 (SPHK1) and vascular endothelial growth factor (VEGF) in patients with endometrial carcinoma and its clinical significance. The tissues of 86 cases of patients with endometrial carcinoma and 54 cases of patients with endometrial atypical hyperplasia were collected. The expression of SPHK1 and VEGF in the tissue was detected by immunohistochemistry. The expression of SPHK1 in patients with endometrial carcinoma was compared with the clinicopathological data. Results. 69 cases (82.1%) of endometrial carcinoma were positive for SPHK1, which was higher than 2 cases (3.7%) of endometrial atypical hyperplasia (P<0.05). The VEGF expression in 54 patients (62.8%) with endometrial carcinoma was higher than that in 12 patients with endometrial atypical hyperplasia (22.2%) (P<0.05). There was a positive correlation between SPHK1 and VEGF expressions in endometrial carcinoma (c = 0.595). The expression of SPHK1 in endometrial cancer patients was different in different pathological types, FIGO stages, lymph node metastasis, ER, and PR positive or not, and the difference between the two groups was significant (P<0.05). There was no difference in age, degree of differentiation, and depth of myometrial infiltration (P<0.05). The expression of SPHK1 in patients with endometrial carcinoma is increased, which is helpful for early detection of patients with endometrial carcinoma, and may play a synergistic role with VEGF in the pathogenesis and development of endometrial carcinoma. |
| first_indexed | 2024-04-11T09:21:50Z |
| format | Article |
| id | doaj.art-cc8cdd1d47ee4b698f6d2baec9a23bbb |
| institution | Directory Open Access Journal |
| issn | 2090-2859 |
| language | English |
| last_indexed | 2024-04-11T09:21:50Z |
| publishDate | 2022-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Emergency Medicine International |
| spelling | doaj.art-cc8cdd1d47ee4b698f6d2baec9a23bbb2022-12-22T04:32:09ZengHindawi LimitedEmergency Medicine International2090-28592022-01-01202210.1155/2022/6716143The Expression and Clinical Significance of Sphingosine Kinase 1 and Vascular Endothelial Growth Factor in Endometrial CarcinomaHong Yu0null Dejizhuoga1Wei Huang2Donglian Wang3null Gamaquzhen4Xiaomin Jia5Hao Feng6Department of PathologyDepartment of PathologyDepartment of GynecologyDepartment of GynecologyDepartment of PathologyDepartment of PathologyDepartment of DermatologyThe aim of the study is to investigate the expression of sphingosine kinase 1 (SPHK1) and vascular endothelial growth factor (VEGF) in patients with endometrial carcinoma and its clinical significance. The tissues of 86 cases of patients with endometrial carcinoma and 54 cases of patients with endometrial atypical hyperplasia were collected. The expression of SPHK1 and VEGF in the tissue was detected by immunohistochemistry. The expression of SPHK1 in patients with endometrial carcinoma was compared with the clinicopathological data. Results. 69 cases (82.1%) of endometrial carcinoma were positive for SPHK1, which was higher than 2 cases (3.7%) of endometrial atypical hyperplasia (P<0.05). The VEGF expression in 54 patients (62.8%) with endometrial carcinoma was higher than that in 12 patients with endometrial atypical hyperplasia (22.2%) (P<0.05). There was a positive correlation between SPHK1 and VEGF expressions in endometrial carcinoma (c = 0.595). The expression of SPHK1 in endometrial cancer patients was different in different pathological types, FIGO stages, lymph node metastasis, ER, and PR positive or not, and the difference between the two groups was significant (P<0.05). There was no difference in age, degree of differentiation, and depth of myometrial infiltration (P<0.05). The expression of SPHK1 in patients with endometrial carcinoma is increased, which is helpful for early detection of patients with endometrial carcinoma, and may play a synergistic role with VEGF in the pathogenesis and development of endometrial carcinoma.http://dx.doi.org/10.1155/2022/6716143 |
| spellingShingle | Hong Yu null Dejizhuoga Wei Huang Donglian Wang null Gamaquzhen Xiaomin Jia Hao Feng The Expression and Clinical Significance of Sphingosine Kinase 1 and Vascular Endothelial Growth Factor in Endometrial Carcinoma Emergency Medicine International |
| title | The Expression and Clinical Significance of Sphingosine Kinase 1 and Vascular Endothelial Growth Factor in Endometrial Carcinoma |
| title_full | The Expression and Clinical Significance of Sphingosine Kinase 1 and Vascular Endothelial Growth Factor in Endometrial Carcinoma |
| title_fullStr | The Expression and Clinical Significance of Sphingosine Kinase 1 and Vascular Endothelial Growth Factor in Endometrial Carcinoma |
| title_full_unstemmed | The Expression and Clinical Significance of Sphingosine Kinase 1 and Vascular Endothelial Growth Factor in Endometrial Carcinoma |
| title_short | The Expression and Clinical Significance of Sphingosine Kinase 1 and Vascular Endothelial Growth Factor in Endometrial Carcinoma |
| title_sort | expression and clinical significance of sphingosine kinase 1 and vascular endothelial growth factor in endometrial carcinoma |
| url | http://dx.doi.org/10.1155/2022/6716143 |
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