Insulin autoimmune syndrome as a cause of recurrent hypoglycemia in a carbimazole user: a case report from Nepal
Vivek Pant,1 Bijay Bhandari,2 Suman Baral,3 Sangha Ratna Bajracharya4 1Department of Clinical Biochemistry, Institute of Medicine (IOM), Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal; 2Department of Clinical Pharmacology, Institute of Medicine (IOM), Tribhuvan University Teaching H...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-02-01
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| Series: | International Medical Case Reports Journal |
| Subjects: | |
| Online Access: | https://www.dovepress.com/insulin-autoimmune-syndrome-as-a-cause-of-recurrent-hypoglycemia-in-a--peer-reviewed-article-IMCRJ |
| _version_ | 1811240099776561152 |
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| author | Pant V Bhandari B Baral S Bajracharya SR |
| author_facet | Pant V Bhandari B Baral S Bajracharya SR |
| author_sort | Pant V |
| collection | DOAJ |
| description | Vivek Pant,1 Bijay Bhandari,2 Suman Baral,3 Sangha Ratna Bajracharya4 1Department of Clinical Biochemistry, Institute of Medicine (IOM), Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal; 2Department of Clinical Pharmacology, Institute of Medicine (IOM), Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal; 3Endocrine Unit, Department of Medicine, Institute of Medicine (IOM), Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal; 4Department of Clinical Pharmacology, Institute of Medicine (IOM), Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal Abstract: Insulin autoimmune syndrome (IAS) is a rare cause of nondiabetic hypoglycemia characterized by hyperinsulinemia and autoantibodies to endogenous insulin without prior exposure to exogenous insulin. We report a drug-induced case of IAS in a 59-year-old Nepalese female. She had been taking carbimazole for Graves’ disease and later presented with recurrent episodes of hypoglycemia, with laboratory findings of low blood glucose, increased molar ratio of insulin to C-peptide, and elevated autoantibodies to insulin. IAS should be considered while evaluating hypoglycemia to prevent unwarranted invasive procedures and surgical interventions. Keywords: insulin autoimmune syndrome, hypoglycemia, carbimazole, Hirata disease |
| first_indexed | 2024-04-12T13:13:16Z |
| format | Article |
| id | doaj.art-cc8e1fd3d8964dd6a93f197d3d0a598b |
| institution | Directory Open Access Journal |
| issn | 1179-142X |
| language | English |
| last_indexed | 2024-04-12T13:13:16Z |
| publishDate | 2019-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Medical Case Reports Journal |
| spelling | doaj.art-cc8e1fd3d8964dd6a93f197d3d0a598b2022-12-22T03:31:47ZengDove Medical PressInternational Medical Case Reports Journal1179-142X2019-02-01Volume 12293243950Insulin autoimmune syndrome as a cause of recurrent hypoglycemia in a carbimazole user: a case report from NepalPant VBhandari BBaral SBajracharya SRVivek Pant,1 Bijay Bhandari,2 Suman Baral,3 Sangha Ratna Bajracharya4 1Department of Clinical Biochemistry, Institute of Medicine (IOM), Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal; 2Department of Clinical Pharmacology, Institute of Medicine (IOM), Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal; 3Endocrine Unit, Department of Medicine, Institute of Medicine (IOM), Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal; 4Department of Clinical Pharmacology, Institute of Medicine (IOM), Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal Abstract: Insulin autoimmune syndrome (IAS) is a rare cause of nondiabetic hypoglycemia characterized by hyperinsulinemia and autoantibodies to endogenous insulin without prior exposure to exogenous insulin. We report a drug-induced case of IAS in a 59-year-old Nepalese female. She had been taking carbimazole for Graves’ disease and later presented with recurrent episodes of hypoglycemia, with laboratory findings of low blood glucose, increased molar ratio of insulin to C-peptide, and elevated autoantibodies to insulin. IAS should be considered while evaluating hypoglycemia to prevent unwarranted invasive procedures and surgical interventions. Keywords: insulin autoimmune syndrome, hypoglycemia, carbimazole, Hirata diseasehttps://www.dovepress.com/insulin-autoimmune-syndrome-as-a-cause-of-recurrent-hypoglycemia-in-a--peer-reviewed-article-IMCRJInsulin autoimmune syndromeHypoglycemiaCarbimazole |
| spellingShingle | Pant V Bhandari B Baral S Bajracharya SR Insulin autoimmune syndrome as a cause of recurrent hypoglycemia in a carbimazole user: a case report from Nepal International Medical Case Reports Journal Insulin autoimmune syndrome Hypoglycemia Carbimazole |
| title | Insulin autoimmune syndrome as a cause of recurrent hypoglycemia in a carbimazole user: a case report from Nepal |
| title_full | Insulin autoimmune syndrome as a cause of recurrent hypoglycemia in a carbimazole user: a case report from Nepal |
| title_fullStr | Insulin autoimmune syndrome as a cause of recurrent hypoglycemia in a carbimazole user: a case report from Nepal |
| title_full_unstemmed | Insulin autoimmune syndrome as a cause of recurrent hypoglycemia in a carbimazole user: a case report from Nepal |
| title_short | Insulin autoimmune syndrome as a cause of recurrent hypoglycemia in a carbimazole user: a case report from Nepal |
| title_sort | insulin autoimmune syndrome as a cause of recurrent hypoglycemia in a carbimazole user a case report from nepal |
| topic | Insulin autoimmune syndrome Hypoglycemia Carbimazole |
| url | https://www.dovepress.com/insulin-autoimmune-syndrome-as-a-cause-of-recurrent-hypoglycemia-in-a--peer-reviewed-article-IMCRJ |
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