Effect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational Study
Driving pressure (ΔP) and mechanical power (MP) are associated with outcomes in critically ill patients, irrespective of the presence of Acute Respiratory Distress Syndrome (ARDS). INTELLiVENT-ASV, a fully automated ventilatory mode, controls the settings that affect ΔP and MP. This study compared t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/22/5409 |
| _version_ | 1797509885397565440 |
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| author | Laura A. Buiteman-Kruizinga Hassan E. Mkadmi Ary Serpa Neto Matthijs D. Kruizinga Michela Botta Marcus J. Schultz Frederique Paulus Pim L.J. van der Heiden |
| author_facet | Laura A. Buiteman-Kruizinga Hassan E. Mkadmi Ary Serpa Neto Matthijs D. Kruizinga Michela Botta Marcus J. Schultz Frederique Paulus Pim L.J. van der Heiden |
| author_sort | Laura A. Buiteman-Kruizinga |
| collection | DOAJ |
| description | Driving pressure (ΔP) and mechanical power (MP) are associated with outcomes in critically ill patients, irrespective of the presence of Acute Respiratory Distress Syndrome (ARDS). INTELLiVENT-ASV, a fully automated ventilatory mode, controls the settings that affect ΔP and MP. This study compared the intensity of ventilation (ΔP and MP) with INTELLiVENT-ASV versus conventional ventilation in a cohort of COVID-19 ARDS patients in two intensive care units in the Netherlands. The coprimary endpoints were ΔP and MP before and after converting from conventional ventilation to INTELLiVENT-ASV. Compared to conventional ventilation, INTELLiVENT-ASV delivered ventilation with a lower ΔP and less MP. With conventional ventilation, ΔP was 13 cmH<sub>2</sub>O, and MP was 21.5 and 24.8 J/min, whereas with INTELLiVENT-ASV, ΔP was 11 and 10 cmH<sub>2</sub>O (mean difference –2 cm H2O (95 %CI –2.5 to –1.2 cm H<sub>2</sub>O), <i>p</i> < 0.001) and MP was 18.8 and 17.5 J/min (mean difference –7.3 J/Min (95% CI –8.8 to –5.8 J/min), <i>p</i> < 0.001). Conversion from conventional ventilation to INTELLiVENT-ASV resulted in a lower intensity of ventilation. These findings may favor the use of INTELLiVENT-ASV in COVID-19 ARDS patients, but future studies remain needed to see if the reduction in the intensity of ventilation translates into clinical benefits. |
| first_indexed | 2024-03-10T05:24:04Z |
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| id | doaj.art-cc9028247f804cc8b78df72338cf4a6e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T05:24:04Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-cc9028247f804cc8b78df72338cf4a6e2023-11-22T23:51:00ZengMDPI AGJournal of Clinical Medicine2077-03832021-11-011022540910.3390/jcm10225409Effect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational StudyLaura A. Buiteman-Kruizinga0Hassan E. Mkadmi1Ary Serpa Neto2Matthijs D. Kruizinga3Michela Botta4Marcus J. Schultz5Frederique Paulus6Pim L.J. van der Heiden7Department of Intensive Care, Reinier de Graaf Hospital, 2625 AD Delft, The NetherlandsDepartment of Research, Reinier de Graaf Hospital, 2625 AD Delft, The NetherlandsDepartment of Intensive Care, Amsterdam University Medical Centers, Location ‘AMC’, 1105 AZ Amsterdam, The NetherlandsDepartment of Pediatrics, Juliana Children’s Hospital, 2545 AA The Hague, The NetherlandsDepartment of Intensive Care, Amsterdam University Medical Centers, Location ‘AMC’, 1105 AZ Amsterdam, The NetherlandsDepartment of Intensive Care, Amsterdam University Medical Centers, Location ‘AMC’, 1105 AZ Amsterdam, The NetherlandsDepartment of Intensive Care, Amsterdam University Medical Centers, Location ‘AMC’, 1105 AZ Amsterdam, The NetherlandsDepartment of Intensive Care, Reinier de Graaf Hospital, 2625 AD Delft, The NetherlandsDriving pressure (ΔP) and mechanical power (MP) are associated with outcomes in critically ill patients, irrespective of the presence of Acute Respiratory Distress Syndrome (ARDS). INTELLiVENT-ASV, a fully automated ventilatory mode, controls the settings that affect ΔP and MP. This study compared the intensity of ventilation (ΔP and MP) with INTELLiVENT-ASV versus conventional ventilation in a cohort of COVID-19 ARDS patients in two intensive care units in the Netherlands. The coprimary endpoints were ΔP and MP before and after converting from conventional ventilation to INTELLiVENT-ASV. Compared to conventional ventilation, INTELLiVENT-ASV delivered ventilation with a lower ΔP and less MP. With conventional ventilation, ΔP was 13 cmH<sub>2</sub>O, and MP was 21.5 and 24.8 J/min, whereas with INTELLiVENT-ASV, ΔP was 11 and 10 cmH<sub>2</sub>O (mean difference –2 cm H2O (95 %CI –2.5 to –1.2 cm H<sub>2</sub>O), <i>p</i> < 0.001) and MP was 18.8 and 17.5 J/min (mean difference –7.3 J/Min (95% CI –8.8 to –5.8 J/min), <i>p</i> < 0.001). Conversion from conventional ventilation to INTELLiVENT-ASV resulted in a lower intensity of ventilation. These findings may favor the use of INTELLiVENT-ASV in COVID-19 ARDS patients, but future studies remain needed to see if the reduction in the intensity of ventilation translates into clinical benefits.https://www.mdpi.com/2077-0383/10/22/5409COVID-19ARDSautomated ventilationclosed-loop ventilationINTELLiVENT-ASVintensity of ventilation |
| spellingShingle | Laura A. Buiteman-Kruizinga Hassan E. Mkadmi Ary Serpa Neto Matthijs D. Kruizinga Michela Botta Marcus J. Schultz Frederique Paulus Pim L.J. van der Heiden Effect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational Study Journal of Clinical Medicine COVID-19 ARDS automated ventilation closed-loop ventilation INTELLiVENT-ASV intensity of ventilation |
| title | Effect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational Study |
| title_full | Effect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational Study |
| title_fullStr | Effect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational Study |
| title_full_unstemmed | Effect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational Study |
| title_short | Effect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational Study |
| title_sort | effect of intellivent asv versus conventional ventilation on ventilation intensity in patients with covid 19 ards an observational study |
| topic | COVID-19 ARDS automated ventilation closed-loop ventilation INTELLiVENT-ASV intensity of ventilation |
| url | https://www.mdpi.com/2077-0383/10/22/5409 |
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