Morbilidade cardiovascular em crianças com infecção pelo vírus da imunodeficiência humana.
Abnormalities of cardiovascular structure and function have been described among children with human immunodeficiency virus (HIV). In order to evaluate their occurrence and clinical predictors, 32 children infected with HIV, aged three months to 13 years (mean age = 3.11 +/- 3.51 years) were studied...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ordem dos Médicos
1998-12-01
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| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2368 |
| _version_ | 1811242236792274944 |
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| author | G Nogueira A J Macedo A Paixão M A Nunes M Ferreira L Bernardino A Bessa L Rosado S Kaku M G Costa |
| author_facet | G Nogueira A J Macedo A Paixão M A Nunes M Ferreira L Bernardino A Bessa L Rosado S Kaku M G Costa |
| author_sort | G Nogueira |
| collection | DOAJ |
| description | Abnormalities of cardiovascular structure and function have been described among children with human immunodeficiency virus (HIV). In order to evaluate their occurrence and clinical predictors, 32 children infected with HIV, aged three months to 13 years (mean age = 3.11 +/- 3.51 years) were studied. Perinatal transmission was identified in 90% of the children. Twenty-two patients (pts) (69%) had symptoms, nine being moderately symptomatic and eight severely symptomatic. Fourteen pts had immunological disturbances and eight of them were severely immunosuppressed. Twenty-eight pts (88%) had HIV-1 infection and 6 recent Ebstein-Barr virus coinfection. Nineteen were on zidovudine and 14 on intravenous immunoglobulin treatment. Nineteen cardiovascular abnormalities were found in 15 pts (47%): 11 cases of pulmonary hypertension by echocardiographic criteria (eight of them had interstitial lung infiltrates seen on chest X-ray) and four cases of left ventricular dysfunction requiring anticongestive therapy. Other abnormalities were: patent ductus arteriosus, septal hypertrophy, mitral valve prolapse and pericardial effusion (one case each). Surface ECG displayed right ventricular hypertrophy in four pts, left ventricular hypertrophy in one patient and unspecific ST-T wave changes in two pts. Fourteen pts (44%) had sinus tachycardia with mean heart rate above the 95th percentile on 24-hour Holter monitoring. CONCLUSIONS: Cardiovascular abnormalities are frequent among children with HIV-1 infection in late stages; pulmonary hypertension is the most frequently found cardiovascular anomaly and seems to be related to either chronic or recurrent respiratory disease; cardiological follow-up is recommended for HIV-infected children. |
| first_indexed | 2024-04-12T13:48:45Z |
| format | Article |
| id | doaj.art-cc924aedd9ba4bdc97969fe257cde444 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-12T13:48:45Z |
| publishDate | 1998-12-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-cc924aedd9ba4bdc97969fe257cde4442022-12-22T03:30:36ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07581998-12-01111210.20344/amp.2368Morbilidade cardiovascular em crianças com infecção pelo vírus da imunodeficiência humana.G Nogueira0A J MacedoA PaixãoM A NunesM FerreiraL BernardinoA BessaL RosadoS KakuM G CostaServiço de Cardiologia Pediátria, Hospital de Santa Marta, Lisboa.Abnormalities of cardiovascular structure and function have been described among children with human immunodeficiency virus (HIV). In order to evaluate their occurrence and clinical predictors, 32 children infected with HIV, aged three months to 13 years (mean age = 3.11 +/- 3.51 years) were studied. Perinatal transmission was identified in 90% of the children. Twenty-two patients (pts) (69%) had symptoms, nine being moderately symptomatic and eight severely symptomatic. Fourteen pts had immunological disturbances and eight of them were severely immunosuppressed. Twenty-eight pts (88%) had HIV-1 infection and 6 recent Ebstein-Barr virus coinfection. Nineteen were on zidovudine and 14 on intravenous immunoglobulin treatment. Nineteen cardiovascular abnormalities were found in 15 pts (47%): 11 cases of pulmonary hypertension by echocardiographic criteria (eight of them had interstitial lung infiltrates seen on chest X-ray) and four cases of left ventricular dysfunction requiring anticongestive therapy. Other abnormalities were: patent ductus arteriosus, septal hypertrophy, mitral valve prolapse and pericardial effusion (one case each). Surface ECG displayed right ventricular hypertrophy in four pts, left ventricular hypertrophy in one patient and unspecific ST-T wave changes in two pts. Fourteen pts (44%) had sinus tachycardia with mean heart rate above the 95th percentile on 24-hour Holter monitoring. CONCLUSIONS: Cardiovascular abnormalities are frequent among children with HIV-1 infection in late stages; pulmonary hypertension is the most frequently found cardiovascular anomaly and seems to be related to either chronic or recurrent respiratory disease; cardiological follow-up is recommended for HIV-infected children.https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2368 |
| spellingShingle | G Nogueira A J Macedo A Paixão M A Nunes M Ferreira L Bernardino A Bessa L Rosado S Kaku M G Costa Morbilidade cardiovascular em crianças com infecção pelo vírus da imunodeficiência humana. Acta Médica Portuguesa |
| title | Morbilidade cardiovascular em crianças com infecção pelo vírus da imunodeficiência humana. |
| title_full | Morbilidade cardiovascular em crianças com infecção pelo vírus da imunodeficiência humana. |
| title_fullStr | Morbilidade cardiovascular em crianças com infecção pelo vírus da imunodeficiência humana. |
| title_full_unstemmed | Morbilidade cardiovascular em crianças com infecção pelo vírus da imunodeficiência humana. |
| title_short | Morbilidade cardiovascular em crianças com infecção pelo vírus da imunodeficiência humana. |
| title_sort | morbilidade cardiovascular em criancas com infeccao pelo virus da imunodeficiencia humana |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2368 |
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