Analytic and Clinical Validation of a Pan-Cancer NGS Liquid Biopsy Test for the Detection of Copy Number Amplifications, Fusions and Exon Skipping Variants

Analytic and Clinical Validation of a Pan-Cancer NGS Liquid Biopsy Test for the Detection of Copy Number Amplifications, Fusions and Exon Skipping Variants

Liquid biopsies are an integral part of the diagnosis of cancer. Here, we have extended previous validation studies of a new targeted NGS panel to include the detection of copy number amplifications (CNAs), fusions, and exon skipping variants. Detection of these gene classes included specimens from...

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Bibliographic Details
Main Authors: Audrey Audetat, Chérie Tschida, Sarah Kreston, Adam Stephen, Brittany D’Alessio, Madeline Bondy, Leisa Jackson, Hestia Mellert, Niki Givens, Ubaradka G. Sathyanarayana, Gary A. Pestano
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Diagnostics
Subjects:
non-small cell lung cancer (NSCLC)
liquid biopsy
cell-free nucleic acid (cfNA)
next generation sequencing (NGS)
CNA (copy number amplifications)
fusions
Online Access:https://www.mdpi.com/2075-4418/12/3/729

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