| Summary: | Impulsive–compulsive and related behavioral disorders (ICD) are drug-induced non-motor symptoms of Parkinson’s disease (PD). Recently research has focused on evaluating whether ICD could be predicted and managed using a pharmacogenetic approach based on dopaminergic therapies, which are the main risk factors. The aim of our study was to evaluate the role of candidate genes such as <i>DBH</i>, <i>DRD2</i>, <i>MAOA</i>, <i>BDNF</i>, <i>COMT</i>, <i>SLC6A4</i>, <i>SLC6A3</i>, <i>ACE</i>, <i>DRD1</i> gene polymorphisms in the pathogenesis of ICD in PD. We compared patients with PD and ICD (<i>n</i> = 49), patients with PD without ICD (<i>n</i> = 36) and a healthy control group (<i>n</i> = 365). ICD was diagnosed using the QUIP questionnaires and specific diagnostic criteria for subtypes of ICD. Genotyping was conducted using a number of PCR techniques and SNaPshot. Statistical analysis was performed using WinPepi and APSampler v3.6 software. PCA testing was conducted using RStudio software v1.4.1106-5. The following substitutions showed statistically significant correlations with PD and ICD: <i>DBH</i> (rs2097629, rs1611115), <i>DRD2</i> (rs6275, rs12364283, rs1076560), <i>ACE</i> (rs4646994), <i>DRD1</i> (rs686), <i>BDNF</i> (rs6265), these associations are novel in Russian PD patients. Our findings suggest that polymorphisms in <i>DBH</i>, <i>BDNF</i>, <i>DRD2</i>, <i>ACE</i> genes in Russian subjects are associated with an increased risk of ICD development.
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