Genetic Markers as Risk Factors for the Development of Impulsive-Compulsive Behaviors in Patients with Parkinson’s Disease Receiving Dopaminergic Therapy
Impulsive–compulsive and related behavioral disorders (ICD) are drug-induced non-motor symptoms of Parkinson’s disease (PD). Recently research has focused on evaluating whether ICD could be predicted and managed using a pharmacogenetic approach based on dopaminergic therapies, which are the main ris...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/12/1321 |
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| author | Anna Fedosova Nataliya Titova Zarema Kokaeva Natalia Shipilova Elena Katunina Eugene Klimov |
| author_facet | Anna Fedosova Nataliya Titova Zarema Kokaeva Natalia Shipilova Elena Katunina Eugene Klimov |
| author_sort | Anna Fedosova |
| collection | DOAJ |
| description | Impulsive–compulsive and related behavioral disorders (ICD) are drug-induced non-motor symptoms of Parkinson’s disease (PD). Recently research has focused on evaluating whether ICD could be predicted and managed using a pharmacogenetic approach based on dopaminergic therapies, which are the main risk factors. The aim of our study was to evaluate the role of candidate genes such as <i>DBH</i>, <i>DRD2</i>, <i>MAOA</i>, <i>BDNF</i>, <i>COMT</i>, <i>SLC6A4</i>, <i>SLC6A3</i>, <i>ACE</i>, <i>DRD1</i> gene polymorphisms in the pathogenesis of ICD in PD. We compared patients with PD and ICD (<i>n</i> = 49), patients with PD without ICD (<i>n</i> = 36) and a healthy control group (<i>n</i> = 365). ICD was diagnosed using the QUIP questionnaires and specific diagnostic criteria for subtypes of ICD. Genotyping was conducted using a number of PCR techniques and SNaPshot. Statistical analysis was performed using WinPepi and APSampler v3.6 software. PCA testing was conducted using RStudio software v1.4.1106-5. The following substitutions showed statistically significant correlations with PD and ICD: <i>DBH</i> (rs2097629, rs1611115), <i>DRD2</i> (rs6275, rs12364283, rs1076560), <i>ACE</i> (rs4646994), <i>DRD1</i> (rs686), <i>BDNF</i> (rs6265), these associations are novel in Russian PD patients. Our findings suggest that polymorphisms in <i>DBH</i>, <i>BDNF</i>, <i>DRD2</i>, <i>ACE</i> genes in Russian subjects are associated with an increased risk of ICD development. |
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| language | English |
| last_indexed | 2024-03-10T03:46:16Z |
| publishDate | 2021-12-01 |
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| series | Journal of Personalized Medicine |
| spelling | doaj.art-cc97c58561d9488488e01885598a94fe2023-11-23T09:07:54ZengMDPI AGJournal of Personalized Medicine2075-44262021-12-011112132110.3390/jpm11121321Genetic Markers as Risk Factors for the Development of Impulsive-Compulsive Behaviors in Patients with Parkinson’s Disease Receiving Dopaminergic TherapyAnna Fedosova0Nataliya Titova1Zarema Kokaeva2Natalia Shipilova3Elena Katunina4Eugene Klimov5Lomonosov Moscow State University, Faculty of Biology, Leninskie Gory, 1, Building 12, 119234 Moscow, RussiaPirogov Russian National Research Medical University, Department of Neurology, Neurosurgery and Medical Genetics, Ostrovitianova, 1, 117997 Moscow, RussiaLomonosov Moscow State University, Faculty of Biology, Leninskie Gory, 1, Building 12, 119234 Moscow, RussiaPirogov Russian National Research Medical University, Department of Neurology, Neurosurgery and Medical Genetics, Ostrovitianova, 1, 117997 Moscow, RussiaPirogov Russian National Research Medical University, Department of Neurology, Neurosurgery and Medical Genetics, Ostrovitianova, 1, 117997 Moscow, RussiaLomonosov Moscow State University, Faculty of Biology, Leninskie Gory, 1, Building 12, 119234 Moscow, RussiaImpulsive–compulsive and related behavioral disorders (ICD) are drug-induced non-motor symptoms of Parkinson’s disease (PD). Recently research has focused on evaluating whether ICD could be predicted and managed using a pharmacogenetic approach based on dopaminergic therapies, which are the main risk factors. The aim of our study was to evaluate the role of candidate genes such as <i>DBH</i>, <i>DRD2</i>, <i>MAOA</i>, <i>BDNF</i>, <i>COMT</i>, <i>SLC6A4</i>, <i>SLC6A3</i>, <i>ACE</i>, <i>DRD1</i> gene polymorphisms in the pathogenesis of ICD in PD. We compared patients with PD and ICD (<i>n</i> = 49), patients with PD without ICD (<i>n</i> = 36) and a healthy control group (<i>n</i> = 365). ICD was diagnosed using the QUIP questionnaires and specific diagnostic criteria for subtypes of ICD. Genotyping was conducted using a number of PCR techniques and SNaPshot. Statistical analysis was performed using WinPepi and APSampler v3.6 software. PCA testing was conducted using RStudio software v1.4.1106-5. The following substitutions showed statistically significant correlations with PD and ICD: <i>DBH</i> (rs2097629, rs1611115), <i>DRD2</i> (rs6275, rs12364283, rs1076560), <i>ACE</i> (rs4646994), <i>DRD1</i> (rs686), <i>BDNF</i> (rs6265), these associations are novel in Russian PD patients. Our findings suggest that polymorphisms in <i>DBH</i>, <i>BDNF</i>, <i>DRD2</i>, <i>ACE</i> genes in Russian subjects are associated with an increased risk of ICD development.https://www.mdpi.com/2075-4426/11/12/1321Parkinson’s disease (PD)impulsive-compulsive disorders (ICD)dopaminergic therapygenetic markerspharmacogeneticpolymorphisms |
| spellingShingle | Anna Fedosova Nataliya Titova Zarema Kokaeva Natalia Shipilova Elena Katunina Eugene Klimov Genetic Markers as Risk Factors for the Development of Impulsive-Compulsive Behaviors in Patients with Parkinson’s Disease Receiving Dopaminergic Therapy Journal of Personalized Medicine Parkinson’s disease (PD) impulsive-compulsive disorders (ICD) dopaminergic therapy genetic markers pharmacogenetic polymorphisms |
| title | Genetic Markers as Risk Factors for the Development of Impulsive-Compulsive Behaviors in Patients with Parkinson’s Disease Receiving Dopaminergic Therapy |
| title_full | Genetic Markers as Risk Factors for the Development of Impulsive-Compulsive Behaviors in Patients with Parkinson’s Disease Receiving Dopaminergic Therapy |
| title_fullStr | Genetic Markers as Risk Factors for the Development of Impulsive-Compulsive Behaviors in Patients with Parkinson’s Disease Receiving Dopaminergic Therapy |
| title_full_unstemmed | Genetic Markers as Risk Factors for the Development of Impulsive-Compulsive Behaviors in Patients with Parkinson’s Disease Receiving Dopaminergic Therapy |
| title_short | Genetic Markers as Risk Factors for the Development of Impulsive-Compulsive Behaviors in Patients with Parkinson’s Disease Receiving Dopaminergic Therapy |
| title_sort | genetic markers as risk factors for the development of impulsive compulsive behaviors in patients with parkinson s disease receiving dopaminergic therapy |
| topic | Parkinson’s disease (PD) impulsive-compulsive disorders (ICD) dopaminergic therapy genetic markers pharmacogenetic polymorphisms |
| url | https://www.mdpi.com/2075-4426/11/12/1321 |
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