Dysfunction of the glymphatic system in childhood absence epilepsy
ObjectiveThis study aimed to evaluate the glymphatic system in childhood absence epilepsy (CAE) using diffusion tensor image analysis along the paravascular space (DTI-ALPS) index. Methods: Forty-two CAE patients and 50 age- and gender-matched healthy controls (HC) were included in this study. All p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1312676/full |
| _version_ | 1827592694244835328 |
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| author | Wanqing Pu Shanzhen Wei Mengdi Qiu Xiaoyu Chen Wenwei Zou Yingchao Ge Wenchao Qiu |
| author_facet | Wanqing Pu Shanzhen Wei Mengdi Qiu Xiaoyu Chen Wenwei Zou Yingchao Ge Wenchao Qiu |
| author_sort | Wanqing Pu |
| collection | DOAJ |
| description | ObjectiveThis study aimed to evaluate the glymphatic system in childhood absence epilepsy (CAE) using diffusion tensor image analysis along the paravascular space (DTI-ALPS) index. Methods: Forty-two CAE patients and 50 age- and gender-matched healthy controls (HC) were included in this study. All participants underwent scanning using a Siemens 3.0 T magnetic resonance scanner, and the DTI-ALPS index was calculated. The study compared the differences of DTI-ALPS index between CAE patients and the healthy controls. Additionally, this study also assessed the relationship between the DTI-ALPS index and clinical characteristics such as age, seizure frequency, and duration of epilepsy.ResultsThe DTI-ALPS index was lower in CAE patients compared to the healthy controls (1.45 ± 0.36 vs. 1.66 ± 0.30, p < 0.01). The DTI-ALPS index showed a negative correlation with the duration of epilepsy (r = −0.48, p < 0.01) and a positive correlation with age (r = 0.766, p < 0.01) in CAE patients. However, no significant correlation was observed between the DTI-ALPS index and seizure frequency.ConclusionThe results of this study indicate that children with CAE exhibit dysfunction in the glymphatic system of the brain, which might contribute to understanding the pathophysiological mechanism of CAE. The DTI-ALPS, as a non-invasive diagnostic marker, can be used to assess the function of the glymphatic system in CAE patients, providing promising applications in the diagnosis and research of CAE. |
| first_indexed | 2024-03-09T01:59:03Z |
| format | Article |
| id | doaj.art-cc9890e29b71489bb3b2220e3c01bc63 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-09T01:59:03Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-cc9890e29b71489bb3b2220e3c01bc632023-12-08T10:51:48ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-12-011710.3389/fnins.2023.13126761312676Dysfunction of the glymphatic system in childhood absence epilepsyWanqing Pu0Shanzhen Wei1Mengdi Qiu2Xiaoyu Chen3Wenwei Zou4Yingchao Ge5Wenchao Qiu6Department of Neurology, The Fifth People’s Hospital of Huai’an, Huai’an, ChinaDepartment of Electrophysiology, The Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, ChinaDepartment of Neurology, The Fifth People’s Hospital of Huai’an, Huai’an, ChinaDepartment of Radiology, The Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, ChinaDepartment of Neurology, The Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, ChinaDepartment of Neurology, Qidong People’s Hospital, Nantong, ChinaDepartment of Neurology, The Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, ChinaObjectiveThis study aimed to evaluate the glymphatic system in childhood absence epilepsy (CAE) using diffusion tensor image analysis along the paravascular space (DTI-ALPS) index. Methods: Forty-two CAE patients and 50 age- and gender-matched healthy controls (HC) were included in this study. All participants underwent scanning using a Siemens 3.0 T magnetic resonance scanner, and the DTI-ALPS index was calculated. The study compared the differences of DTI-ALPS index between CAE patients and the healthy controls. Additionally, this study also assessed the relationship between the DTI-ALPS index and clinical characteristics such as age, seizure frequency, and duration of epilepsy.ResultsThe DTI-ALPS index was lower in CAE patients compared to the healthy controls (1.45 ± 0.36 vs. 1.66 ± 0.30, p < 0.01). The DTI-ALPS index showed a negative correlation with the duration of epilepsy (r = −0.48, p < 0.01) and a positive correlation with age (r = 0.766, p < 0.01) in CAE patients. However, no significant correlation was observed between the DTI-ALPS index and seizure frequency.ConclusionThe results of this study indicate that children with CAE exhibit dysfunction in the glymphatic system of the brain, which might contribute to understanding the pathophysiological mechanism of CAE. The DTI-ALPS, as a non-invasive diagnostic marker, can be used to assess the function of the glymphatic system in CAE patients, providing promising applications in the diagnosis and research of CAE.https://www.frontiersin.org/articles/10.3389/fnins.2023.1312676/fulldiffusion tensor imagingDTI-ALPSchildhood absence epilepsyglymphatic systemneuroimage biomarker |
| spellingShingle | Wanqing Pu Shanzhen Wei Mengdi Qiu Xiaoyu Chen Wenwei Zou Yingchao Ge Wenchao Qiu Dysfunction of the glymphatic system in childhood absence epilepsy Frontiers in Neuroscience diffusion tensor imaging DTI-ALPS childhood absence epilepsy glymphatic system neuroimage biomarker |
| title | Dysfunction of the glymphatic system in childhood absence epilepsy |
| title_full | Dysfunction of the glymphatic system in childhood absence epilepsy |
| title_fullStr | Dysfunction of the glymphatic system in childhood absence epilepsy |
| title_full_unstemmed | Dysfunction of the glymphatic system in childhood absence epilepsy |
| title_short | Dysfunction of the glymphatic system in childhood absence epilepsy |
| title_sort | dysfunction of the glymphatic system in childhood absence epilepsy |
| topic | diffusion tensor imaging DTI-ALPS childhood absence epilepsy glymphatic system neuroimage biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1312676/full |
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