Individual variations and sex differences in hemodynamics with percutaneous arterial oxygen saturation (SpO2) in young Andean highlanders in Bolivia
Abstract Background Many studies have reported specific adaptations to high altitude, but few studies have focused on physiological variations in high-altitude adaptation in Andean highlanders. This study aimed to investigate the relationships between SpO2 and related factors, including individual v...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | Journal of Physiological Anthropology |
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| Online Access: | http://link.springer.com/article/10.1186/s40101-020-00240-y |
| _version_ | 1818656058602684416 |
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| author | Takayuki Nishimura Juan Ugarte Mayumi Ohnishi Mika Nishihara Guillermo Alvarez Yoshiki Yasukochi Hideki Fukuda Kazuhiko Arima Shigeki Watanuki Victor Mendoza Kiyoshi Aoyagi |
| author_facet | Takayuki Nishimura Juan Ugarte Mayumi Ohnishi Mika Nishihara Guillermo Alvarez Yoshiki Yasukochi Hideki Fukuda Kazuhiko Arima Shigeki Watanuki Victor Mendoza Kiyoshi Aoyagi |
| author_sort | Takayuki Nishimura |
| collection | DOAJ |
| description | Abstract Background Many studies have reported specific adaptations to high altitude, but few studies have focused on physiological variations in high-altitude adaptation in Andean highlanders. This study aimed to investigate the relationships between SpO2 and related factors, including individual variations and sex differences, in Andean highlanders. Methods The participants were community-dwelling people in La Paz, Bolivia, aged 20 years and over (age range 20–34 years). A total of 50 men and 50 women participated in this study. Height, weight, SpO2, hemoglobin concentration, finger temperature, heart rate, and blood pressure were measured. Information about lifestyle was also obtained by interview. Results There were individual variations of SpO2 both in men (mean 89.9%, range 84.0–95.0%) and women (mean 91.0%, range 84.0–96.0%). On Student’s t test, men had significantly lower heart rate (p = 0.046) and SpO2 (p = 0.030) than women. On the other hand, men had significantly higher SBP (p < 0.001), hemoglobin (p < 0.001), and finger temperature (p = 0.004). In men, multiple stepwise regression analysis showed that a higher SpO2 was correlated with a lower heart rate (β = − 0.089, p = 0.007) and a higher finger temperature (β = 0.308, p = 0.030) (r 2 for model = 0.18). In women, a higher SpO2 was significantly correlated with a higher finger temperature (β = 0.391, p = 0.015) (r 2 for model = 0.12). A higher SpO2 was related to a higher finger temperature (β = 0.286, p = 0.014) and a lower heart rate (β = − 0.052, p = 0.029) in all participants (r 2 for model = 0.21). Residual analysis showed that individual SpO2 values were randomly plotted. Conclusion Random plots of SpO2 on residual analysis indicated that these variations were random error, such as biological variation. A higher SpO2 was related to a lower heart rate and finger temperature in men, but a higher SpO2 was related to finger temperature in women. These results suggest that there are individual variations and sex differences in the hemodynamic responses of high-altitude adaptation in Andean highlanders. |
| first_indexed | 2024-12-17T03:19:33Z |
| format | Article |
| id | doaj.art-cc98c31f668c4b54955ce5c880ecff31 |
| institution | Directory Open Access Journal |
| issn | 1880-6805 |
| language | English |
| last_indexed | 2024-12-17T03:19:33Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Physiological Anthropology |
| spelling | doaj.art-cc98c31f668c4b54955ce5c880ecff312022-12-21T22:05:33ZengBMCJournal of Physiological Anthropology1880-68052020-10-013911810.1186/s40101-020-00240-yIndividual variations and sex differences in hemodynamics with percutaneous arterial oxygen saturation (SpO2) in young Andean highlanders in BoliviaTakayuki Nishimura0Juan Ugarte1Mayumi Ohnishi2Mika Nishihara3Guillermo Alvarez4Yoshiki Yasukochi5Hideki Fukuda6Kazuhiko Arima7Shigeki Watanuki8Victor Mendoza9Kiyoshi Aoyagi10Department of Public Health, Nagasaki University Graduate School of Biomedical SciencesFaculty of Dentistry, Universidad Mayor de San AndresDepartment of Health Sciences, Nagasaki University Graduate School of Biomedical SciencesDepartment of Health Sciences, Nagasaki University Graduate School of Biomedical SciencesFaculty of Dentistry, Universidad Mayor de San AndresDepartment of Human Functional Genomics, Advanced Science Research Promotion Center, Organization for the Promotion of Regional Innovation, Mie UniversityNational Institute of Public HealthDepartment of Public Health, Nagasaki University Graduate School of Biomedical SciencesDepartment of Human Science, Kyushu UniversityFaculty of Dentistry, Universidad Mayor de San AndresDepartment of Public Health, Nagasaki University Graduate School of Biomedical SciencesAbstract Background Many studies have reported specific adaptations to high altitude, but few studies have focused on physiological variations in high-altitude adaptation in Andean highlanders. This study aimed to investigate the relationships between SpO2 and related factors, including individual variations and sex differences, in Andean highlanders. Methods The participants were community-dwelling people in La Paz, Bolivia, aged 20 years and over (age range 20–34 years). A total of 50 men and 50 women participated in this study. Height, weight, SpO2, hemoglobin concentration, finger temperature, heart rate, and blood pressure were measured. Information about lifestyle was also obtained by interview. Results There were individual variations of SpO2 both in men (mean 89.9%, range 84.0–95.0%) and women (mean 91.0%, range 84.0–96.0%). On Student’s t test, men had significantly lower heart rate (p = 0.046) and SpO2 (p = 0.030) than women. On the other hand, men had significantly higher SBP (p < 0.001), hemoglobin (p < 0.001), and finger temperature (p = 0.004). In men, multiple stepwise regression analysis showed that a higher SpO2 was correlated with a lower heart rate (β = − 0.089, p = 0.007) and a higher finger temperature (β = 0.308, p = 0.030) (r 2 for model = 0.18). In women, a higher SpO2 was significantly correlated with a higher finger temperature (β = 0.391, p = 0.015) (r 2 for model = 0.12). A higher SpO2 was related to a higher finger temperature (β = 0.286, p = 0.014) and a lower heart rate (β = − 0.052, p = 0.029) in all participants (r 2 for model = 0.21). Residual analysis showed that individual SpO2 values were randomly plotted. Conclusion Random plots of SpO2 on residual analysis indicated that these variations were random error, such as biological variation. A higher SpO2 was related to a lower heart rate and finger temperature in men, but a higher SpO2 was related to finger temperature in women. These results suggest that there are individual variations and sex differences in the hemodynamic responses of high-altitude adaptation in Andean highlanders.http://link.springer.com/article/10.1186/s40101-020-00240-yHigh altitude adaptationSpO2Physiological variationSex differenceAndean highlanders |
| spellingShingle | Takayuki Nishimura Juan Ugarte Mayumi Ohnishi Mika Nishihara Guillermo Alvarez Yoshiki Yasukochi Hideki Fukuda Kazuhiko Arima Shigeki Watanuki Victor Mendoza Kiyoshi Aoyagi Individual variations and sex differences in hemodynamics with percutaneous arterial oxygen saturation (SpO2) in young Andean highlanders in Bolivia Journal of Physiological Anthropology High altitude adaptation SpO2 Physiological variation Sex difference Andean highlanders |
| title | Individual variations and sex differences in hemodynamics with percutaneous arterial oxygen saturation (SpO2) in young Andean highlanders in Bolivia |
| title_full | Individual variations and sex differences in hemodynamics with percutaneous arterial oxygen saturation (SpO2) in young Andean highlanders in Bolivia |
| title_fullStr | Individual variations and sex differences in hemodynamics with percutaneous arterial oxygen saturation (SpO2) in young Andean highlanders in Bolivia |
| title_full_unstemmed | Individual variations and sex differences in hemodynamics with percutaneous arterial oxygen saturation (SpO2) in young Andean highlanders in Bolivia |
| title_short | Individual variations and sex differences in hemodynamics with percutaneous arterial oxygen saturation (SpO2) in young Andean highlanders in Bolivia |
| title_sort | individual variations and sex differences in hemodynamics with percutaneous arterial oxygen saturation spo2 in young andean highlanders in bolivia |
| topic | High altitude adaptation SpO2 Physiological variation Sex difference Andean highlanders |
| url | http://link.springer.com/article/10.1186/s40101-020-00240-y |
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