Association between health-related quality of life and heart rate variability in elderly individuals with cognitive impairment in Korea: cross-sectional study
Abstract Background Cognitive impairment, a characteristic and prior stage of dementia, is a serious public health concern in Korea a country with rapidly aging population. In a neurovisceral integration model, cognitive ability is connected to emotional and autonomic regulation via an interconnecti...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-023-04529-2 |
| _version_ | 1797388088869126144 |
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| author | Donghoon Kim Jaeho Lee Ju-Young Choi Hyo-Jung Lee Jin-Young Min Kyoung-Bok Min |
| author_facet | Donghoon Kim Jaeho Lee Ju-Young Choi Hyo-Jung Lee Jin-Young Min Kyoung-Bok Min |
| author_sort | Donghoon Kim |
| collection | DOAJ |
| description | Abstract Background Cognitive impairment, a characteristic and prior stage of dementia, is a serious public health concern in Korea a country with rapidly aging population. In a neurovisceral integration model, cognitive ability is connected to emotional and autonomic regulation via an interconnection in the brain, which may be associated with health-related quality of life (HRQoL). Methods This study investigated the association between the HRQoL and the autonomic nervous system (ANS) via EuroQoL-5 Dimension (EQ-5D) and heart rate variability (HRV) among 417 patients who visited the Neurology Department in Veterans Health Service Medical Center, Seoul, South Korea. Results The mean age of 275 patients in the cognitive impairment group (CIG) was higher than that of 142 patients in the normal cognition group (NCG) (74.85 years vs. 72.96 years, p < 0.001). In a generalized linear model with a beta coefficient (β), an increase in HRQoL was associated with higher HRV levels was observed only in CIG (CIG: the standard deviation of all NN intervals (SDNN) (ln, ms): β = 0.02, p = 0.007; Total power spectral density (TP) (ln, ms2): β = 0.01, p = 0.007; High frequency (HF) (ln, ms2): β = 0.01, p = 0.015; Low frequency (LF) (ln, ms2): β = 0.01, p = 0.003) (NCG: SDNN (ln, ms): β = 0.01, p = 0.214; TP (ln, ms2): β = 0.01, p = 0.144; HF (ln, ms2): β = 0.00, p = 0.249; LF (ln, ms2): β = 0.01, p = 0.294). Conclusions We found a significant association between HRQoL and HRV in Korean elders with cognitive impairment. However, this study is cross-sectional, so we cannot define direct causation. Further studies are needed to support our findings and to elucidate the biological mechanisms underlying these associations, especially in people cognitively impaired. |
| first_indexed | 2024-03-08T22:35:44Z |
| format | Article |
| id | doaj.art-cc9907e261154dffa64216dc0795d731 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-03-08T22:35:44Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-cc9907e261154dffa64216dc0795d7312023-12-17T12:29:21ZengBMCBMC Geriatrics1471-23182023-12-012311910.1186/s12877-023-04529-2Association between health-related quality of life and heart rate variability in elderly individuals with cognitive impairment in Korea: cross-sectional studyDonghoon Kim0Jaeho Lee1Ju-Young Choi2Hyo-Jung Lee3Jin-Young Min4Kyoung-Bok Min5Department of Preventive Medicine, Seoul National University College of MedicineDepartment of Preventive Medicine, Seoul National University College of MedicineDepartment of Preventive Medicine, Seoul National University College of MedicineDepartment of Preventive Medicine, Seoul National University College of MedicineVeterans Medical Research Institute, Veterans Health Service Medical CenterDepartment of Preventive Medicine, Seoul National University College of MedicineAbstract Background Cognitive impairment, a characteristic and prior stage of dementia, is a serious public health concern in Korea a country with rapidly aging population. In a neurovisceral integration model, cognitive ability is connected to emotional and autonomic regulation via an interconnection in the brain, which may be associated with health-related quality of life (HRQoL). Methods This study investigated the association between the HRQoL and the autonomic nervous system (ANS) via EuroQoL-5 Dimension (EQ-5D) and heart rate variability (HRV) among 417 patients who visited the Neurology Department in Veterans Health Service Medical Center, Seoul, South Korea. Results The mean age of 275 patients in the cognitive impairment group (CIG) was higher than that of 142 patients in the normal cognition group (NCG) (74.85 years vs. 72.96 years, p < 0.001). In a generalized linear model with a beta coefficient (β), an increase in HRQoL was associated with higher HRV levels was observed only in CIG (CIG: the standard deviation of all NN intervals (SDNN) (ln, ms): β = 0.02, p = 0.007; Total power spectral density (TP) (ln, ms2): β = 0.01, p = 0.007; High frequency (HF) (ln, ms2): β = 0.01, p = 0.015; Low frequency (LF) (ln, ms2): β = 0.01, p = 0.003) (NCG: SDNN (ln, ms): β = 0.01, p = 0.214; TP (ln, ms2): β = 0.01, p = 0.144; HF (ln, ms2): β = 0.00, p = 0.249; LF (ln, ms2): β = 0.01, p = 0.294). Conclusions We found a significant association between HRQoL and HRV in Korean elders with cognitive impairment. However, this study is cross-sectional, so we cannot define direct causation. Further studies are needed to support our findings and to elucidate the biological mechanisms underlying these associations, especially in people cognitively impaired.https://doi.org/10.1186/s12877-023-04529-2Cognitive impairmentHeart rate variabilityQuality of lifeKorean |
| spellingShingle | Donghoon Kim Jaeho Lee Ju-Young Choi Hyo-Jung Lee Jin-Young Min Kyoung-Bok Min Association between health-related quality of life and heart rate variability in elderly individuals with cognitive impairment in Korea: cross-sectional study BMC Geriatrics Cognitive impairment Heart rate variability Quality of life Korean |
| title | Association between health-related quality of life and heart rate variability in elderly individuals with cognitive impairment in Korea: cross-sectional study |
| title_full | Association between health-related quality of life and heart rate variability in elderly individuals with cognitive impairment in Korea: cross-sectional study |
| title_fullStr | Association between health-related quality of life and heart rate variability in elderly individuals with cognitive impairment in Korea: cross-sectional study |
| title_full_unstemmed | Association between health-related quality of life and heart rate variability in elderly individuals with cognitive impairment in Korea: cross-sectional study |
| title_short | Association between health-related quality of life and heart rate variability in elderly individuals with cognitive impairment in Korea: cross-sectional study |
| title_sort | association between health related quality of life and heart rate variability in elderly individuals with cognitive impairment in korea cross sectional study |
| topic | Cognitive impairment Heart rate variability Quality of life Korean |
| url | https://doi.org/10.1186/s12877-023-04529-2 |
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