Neural Circuitry of Salience and Reward Processing in Psychosis
The processing of salient and rewarding stimuli is integral to engaging our attention, stimulating anticipation for future events, and driving goal-directed behaviors. Widespread impairments in these processes are observed in psychosis, which may be associated with worse functional outcomes or mecha...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
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| Series: | Biological Psychiatry Global Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667174321001592 |
| _version_ | 1797948274274992128 |
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| author | James P. Kesby Graham K. Murray Franziska Knolle |
| author_facet | James P. Kesby Graham K. Murray Franziska Knolle |
| author_sort | James P. Kesby |
| collection | DOAJ |
| description | The processing of salient and rewarding stimuli is integral to engaging our attention, stimulating anticipation for future events, and driving goal-directed behaviors. Widespread impairments in these processes are observed in psychosis, which may be associated with worse functional outcomes or mechanistically linked to the development of symptoms. Here, we summarize the current knowledge of behavioral and functional neuroimaging in salience, prediction error, and reward. Although each is a specific process, they are situated in multiple feedback and feedforward systems integral to decision making and cognition more generally. We argue that the origin of salience and reward processing dysfunctions may be centered in the subcortex during the earliest stages of psychosis, with cortical abnormalities being initially more spared but becoming more prominent in established psychotic illness/schizophrenia. The neural circuits underpinning salience and reward processing may provide targets for delaying or preventing progressive behavioral and neurobiological decline. |
| first_indexed | 2024-04-10T21:40:43Z |
| format | Article |
| id | doaj.art-cc9ac7bea41f4af2a9c4412b202b0816 |
| institution | Directory Open Access Journal |
| issn | 2667-1743 |
| language | English |
| last_indexed | 2024-04-10T21:40:43Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biological Psychiatry Global Open Science |
| spelling | doaj.art-cc9ac7bea41f4af2a9c4412b202b08162023-01-19T04:17:57ZengElsevierBiological Psychiatry Global Open Science2667-17432023-01-01313346Neural Circuitry of Salience and Reward Processing in PsychosisJames P. Kesby0Graham K. Murray1Franziska Knolle2Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Address correspondence to James Kesby, Ph.D.Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia; Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United KingdomDepartment of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany; Franziska Knolle, Ph.D.The processing of salient and rewarding stimuli is integral to engaging our attention, stimulating anticipation for future events, and driving goal-directed behaviors. Widespread impairments in these processes are observed in psychosis, which may be associated with worse functional outcomes or mechanistically linked to the development of symptoms. Here, we summarize the current knowledge of behavioral and functional neuroimaging in salience, prediction error, and reward. Although each is a specific process, they are situated in multiple feedback and feedforward systems integral to decision making and cognition more generally. We argue that the origin of salience and reward processing dysfunctions may be centered in the subcortex during the earliest stages of psychosis, with cortical abnormalities being initially more spared but becoming more prominent in established psychotic illness/schizophrenia. The neural circuits underpinning salience and reward processing may provide targets for delaying or preventing progressive behavioral and neurobiological decline.http://www.sciencedirect.com/science/article/pii/S2667174321001592DopamineNucleus accumbensPrediction errorPsychosisPunishmentReward |
| spellingShingle | James P. Kesby Graham K. Murray Franziska Knolle Neural Circuitry of Salience and Reward Processing in Psychosis Biological Psychiatry Global Open Science Dopamine Nucleus accumbens Prediction error Psychosis Punishment Reward |
| title | Neural Circuitry of Salience and Reward Processing in Psychosis |
| title_full | Neural Circuitry of Salience and Reward Processing in Psychosis |
| title_fullStr | Neural Circuitry of Salience and Reward Processing in Psychosis |
| title_full_unstemmed | Neural Circuitry of Salience and Reward Processing in Psychosis |
| title_short | Neural Circuitry of Salience and Reward Processing in Psychosis |
| title_sort | neural circuitry of salience and reward processing in psychosis |
| topic | Dopamine Nucleus accumbens Prediction error Psychosis Punishment Reward |
| url | http://www.sciencedirect.com/science/article/pii/S2667174321001592 |
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