Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells
Cancers arising from the gastric squamous-columnar junction have high incidence and are characterized by a poor prognosis. Here, the authors use genetic mouse models to show that loss of p53 and Rb1 expression results in preferential tumour development at the gastric squamous-columnar junction that...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13847-2 |
| _version_ | 1818857808065462272 |
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| author | Dah-Jiun Fu Lianghai Wang Fouad K. Chouairi Ian M. Rose Danysh A. Abetov Andrew D. Miller Robert J. Yamulla John C. Schimenti Andrea Flesken-Nikitin Alexander Yu. Nikitin |
| author_facet | Dah-Jiun Fu Lianghai Wang Fouad K. Chouairi Ian M. Rose Danysh A. Abetov Andrew D. Miller Robert J. Yamulla John C. Schimenti Andrea Flesken-Nikitin Alexander Yu. Nikitin |
| author_sort | Dah-Jiun Fu |
| collection | DOAJ |
| description | Cancers arising from the gastric squamous-columnar junction have high incidence and are characterized by a poor prognosis. Here, the authors use genetic mouse models to show that loss of p53 and Rb1 expression results in preferential tumour development at the gastric squamous-columnar junction that contains a large pool of osteopontin responsive Lgr5-CD44+ cells. |
| first_indexed | 2024-12-19T08:46:07Z |
| format | Article |
| id | doaj.art-cc9b087fae6a467297a9cdf23f9d6ec2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:46:07Z |
| publishDate | 2020-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-cc9b087fae6a467297a9cdf23f9d6ec22022-12-21T20:28:49ZengNature PortfolioNature Communications2041-17232020-01-0111111310.1038/s41467-019-13847-2Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cellsDah-Jiun Fu0Lianghai Wang1Fouad K. Chouairi2Ian M. Rose3Danysh A. Abetov4Andrew D. Miller5Robert J. Yamulla6John C. Schimenti7Andrea Flesken-Nikitin8Alexander Yu. Nikitin9Department of Biomedical Sciences and Cornell Stem Cell Program, Cornell UniversityDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell UniversityDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell UniversityDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell UniversityDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell UniversityDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell UniversityDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell UniversityDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell UniversityDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell UniversityDepartment of Biomedical Sciences and Cornell Stem Cell Program, Cornell UniversityCancers arising from the gastric squamous-columnar junction have high incidence and are characterized by a poor prognosis. Here, the authors use genetic mouse models to show that loss of p53 and Rb1 expression results in preferential tumour development at the gastric squamous-columnar junction that contains a large pool of osteopontin responsive Lgr5-CD44+ cells.https://doi.org/10.1038/s41467-019-13847-2 |
| spellingShingle | Dah-Jiun Fu Lianghai Wang Fouad K. Chouairi Ian M. Rose Danysh A. Abetov Andrew D. Miller Robert J. Yamulla John C. Schimenti Andrea Flesken-Nikitin Alexander Yu. Nikitin Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells Nature Communications |
| title | Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells |
| title_full | Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells |
| title_fullStr | Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells |
| title_full_unstemmed | Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells |
| title_short | Gastric squamous-columnar junction contains a large pool of cancer-prone immature osteopontin responsive Lgr5−CD44+ cells |
| title_sort | gastric squamous columnar junction contains a large pool of cancer prone immature osteopontin responsive lgr5 cd44 cells |
| url | https://doi.org/10.1038/s41467-019-13847-2 |
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