Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells

Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells

Antigen uptake by dendritic cells and intracellular routing of antigens to specific compartments is regulated by C-type lectin receptors that recognize glycan structures. We show that the modification of Ovalbumin (OVA) with the glycan-structure LewisX (LeX) re-directs OVA to the C-type lectin recep...

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Bibliographic Details
Main Authors: Ingeborg Streng-Ouwehand, Nataschja I Ho, Manja Litjens, Hakan Kalay, Martine Annemarie Boks, Lenneke AM Cornelissen, Satwinder Kaur Singh, Eirikur Saeland, Juan J Garcia-Vallejo, Ferry A Ossendorp, Wendy WJ Unger, Yvette van Kooyk
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
dendritic cells
cross-presentation
T cell priming
glycosylation
MGL1
Online Access:https://elifesciences.org/articles/11765

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