Prostate Cancer Microvascular Routes: Exploration and Measurement Strategies
Angiogenesis is acknowledged as a pivotal feature in the pathology of human cancer. Despite the absence of universally accepted markers for gauging the comprehensive angiogenic activity in prostate cancer (PCa) that could steer the formulation of focused anti-angiogenic treatments, the scrutiny of d...
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MDPI AG
2023-10-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/10/2034 |
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| author | Fabio Grizzi Mohamed A. A. A. Hegazi Matteo Zanoni Paolo Vota Giovanni Toia Maria Chiara Clementi Cinzia Mazzieri Maurizio Chiriva-Internati Gianluigi Taverna |
| author_facet | Fabio Grizzi Mohamed A. A. A. Hegazi Matteo Zanoni Paolo Vota Giovanni Toia Maria Chiara Clementi Cinzia Mazzieri Maurizio Chiriva-Internati Gianluigi Taverna |
| author_sort | Fabio Grizzi |
| collection | DOAJ |
| description | Angiogenesis is acknowledged as a pivotal feature in the pathology of human cancer. Despite the absence of universally accepted markers for gauging the comprehensive angiogenic activity in prostate cancer (PCa) that could steer the formulation of focused anti-angiogenic treatments, the scrutiny of diverse facets of tumoral blood vessel development may furnish significant understanding of angiogenic processes. Malignant neoplasms, encompassing PCa, deploy a myriad of strategies to secure an adequate blood supply. These modalities range from sprouting angiogenesis and vasculogenesis to intussusceptive angiogenesis, vascular co-option, the formation of mosaic vessels, vasculogenic mimicry, the conversion of cancer stem-like cells into tumor endothelial cells, and vascular pruning. Here we provide a thorough review of these angiogenic mechanisms as they relate to PCa, discuss their prospective relevance for predictive and prognostic evaluations, and outline the prevailing obstacles in quantitatively evaluating neovascularization via histopathological examinations. |
| first_indexed | 2024-03-10T21:07:16Z |
| format | Article |
| id | doaj.art-cc9bb30f3952470896b10fa482e2a3db |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T21:07:16Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-cc9bb30f3952470896b10fa482e2a3db2023-11-19T17:06:27ZengMDPI AGLife2075-17292023-10-011310203410.3390/life13102034Prostate Cancer Microvascular Routes: Exploration and Measurement StrategiesFabio Grizzi0Mohamed A. A. A. Hegazi1Matteo Zanoni2Paolo Vota3Giovanni Toia4Maria Chiara Clementi5Cinzia Mazzieri6Maurizio Chiriva-Internati7Gianluigi Taverna8Department of Immunology and Inflammation, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyDepartment of Immunology and Inflammation, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, ItalyDepartment of Urology, Humanitas Mater Domini, Castellanza, 21053 Varese, ItalyDepartment of Urology, Humanitas Mater Domini, Castellanza, 21053 Varese, ItalyDepartment of Urology, Humanitas Mater Domini, Castellanza, 21053 Varese, ItalyDepartment of Urology, Humanitas Mater Domini, Castellanza, 21053 Varese, ItalyDepartment of Urology, Humanitas Mater Domini, Castellanza, 21053 Varese, ItalyDepartments of Gastroenterology, Hepatology & Nutrition, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, ItalyAngiogenesis is acknowledged as a pivotal feature in the pathology of human cancer. Despite the absence of universally accepted markers for gauging the comprehensive angiogenic activity in prostate cancer (PCa) that could steer the formulation of focused anti-angiogenic treatments, the scrutiny of diverse facets of tumoral blood vessel development may furnish significant understanding of angiogenic processes. Malignant neoplasms, encompassing PCa, deploy a myriad of strategies to secure an adequate blood supply. These modalities range from sprouting angiogenesis and vasculogenesis to intussusceptive angiogenesis, vascular co-option, the formation of mosaic vessels, vasculogenic mimicry, the conversion of cancer stem-like cells into tumor endothelial cells, and vascular pruning. Here we provide a thorough review of these angiogenic mechanisms as they relate to PCa, discuss their prospective relevance for predictive and prognostic evaluations, and outline the prevailing obstacles in quantitatively evaluating neovascularization via histopathological examinations.https://www.mdpi.com/2075-1729/13/10/2034prostate cancervasculaturemicrovessel densitybiomarkersfractals |
| spellingShingle | Fabio Grizzi Mohamed A. A. A. Hegazi Matteo Zanoni Paolo Vota Giovanni Toia Maria Chiara Clementi Cinzia Mazzieri Maurizio Chiriva-Internati Gianluigi Taverna Prostate Cancer Microvascular Routes: Exploration and Measurement Strategies Life prostate cancer vasculature microvessel density biomarkers fractals |
| title | Prostate Cancer Microvascular Routes: Exploration and Measurement Strategies |
| title_full | Prostate Cancer Microvascular Routes: Exploration and Measurement Strategies |
| title_fullStr | Prostate Cancer Microvascular Routes: Exploration and Measurement Strategies |
| title_full_unstemmed | Prostate Cancer Microvascular Routes: Exploration and Measurement Strategies |
| title_short | Prostate Cancer Microvascular Routes: Exploration and Measurement Strategies |
| title_sort | prostate cancer microvascular routes exploration and measurement strategies |
| topic | prostate cancer vasculature microvessel density biomarkers fractals |
| url | https://www.mdpi.com/2075-1729/13/10/2034 |
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