Adiponectin preserves metabolic fitness during aging
Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects of adiponectin on promoting healthspan and lifespa...
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Language: | English |
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eLife Sciences Publications Ltd
2021-04-01
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Series: | eLife |
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Online Access: | https://elifesciences.org/articles/65108 |
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author | Na Li Shangang Zhao Zhuzhen Zhang Yi Zhu Christy M Gliniak Lavanya Vishvanath Yu A An May-yun Wang Yingfeng Deng Qingzhang Zhu Bo Shan Amber Sherwood Toshiharu Onodera Orhan K Oz Ruth Gordillo Rana K Gupta Ming Liu Tamas L Horvath Vishwa Deep Dixit Philipp E Scherer |
author_facet | Na Li Shangang Zhao Zhuzhen Zhang Yi Zhu Christy M Gliniak Lavanya Vishvanath Yu A An May-yun Wang Yingfeng Deng Qingzhang Zhu Bo Shan Amber Sherwood Toshiharu Onodera Orhan K Oz Ruth Gordillo Rana K Gupta Ming Liu Tamas L Horvath Vishwa Deep Dixit Philipp E Scherer |
author_sort | Na Li |
collection | DOAJ |
description | Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects of adiponectin on promoting healthspan and lifespan remain unexplored. Here, we are using an adiponectin null mouse and a transgenic adiponectin overexpression model. We directly assessed the effects of circulating adiponectin on the aging process and found that adiponectin null mice display exacerbated age-related glucose and lipid metabolism disorders. Moreover, adiponectin null mice have a significantly shortened lifespan on both chow and high-fat diet. In contrast, a transgenic mouse model with elevated circulating adiponectin levels has a dramatically improved systemic insulin sensitivity, reduced age-related tissue inflammation and fibrosis, and a prolonged healthspan and median lifespan. These results support a role of adiponectin as an essential regulator for healthspan and lifespan. |
first_indexed | 2024-04-12T02:26:05Z |
format | Article |
id | doaj.art-cc9c31e77b504b8e89c7e9bde51878cd |
institution | Directory Open Access Journal |
issn | 2050-084X |
language | English |
last_indexed | 2024-04-12T02:26:05Z |
publishDate | 2021-04-01 |
publisher | eLife Sciences Publications Ltd |
record_format | Article |
series | eLife |
spelling | doaj.art-cc9c31e77b504b8e89c7e9bde51878cd2022-12-22T03:52:00ZengeLife Sciences Publications LtdeLife2050-084X2021-04-011010.7554/eLife.65108Adiponectin preserves metabolic fitness during agingNa Li0https://orcid.org/0000-0002-0604-6312Shangang Zhao1https://orcid.org/0000-0002-9209-8206Zhuzhen Zhang2https://orcid.org/0000-0001-6787-3920Yi Zhu3Christy M Gliniak4Lavanya Vishvanath5Yu A An6https://orcid.org/0000-0002-9678-3382May-yun Wang7Yingfeng Deng8https://orcid.org/0000-0003-1314-5105Qingzhang Zhu9Bo Shan10Amber Sherwood11Toshiharu Onodera12https://orcid.org/0000-0002-4439-0077Orhan K Oz13Ruth Gordillo14Rana K Gupta15https://orcid.org/0000-0002-9001-4531Ming Liu16https://orcid.org/0000-0003-2665-4072Tamas L Horvath17https://orcid.org/0000-0002-7522-4602Vishwa Deep Dixit18https://orcid.org/0000-0002-5341-6494Philipp E Scherer19https://orcid.org/0000-0003-0680-3392Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States; Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, ChinaTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesDepartment of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Comparative Medicine and Immunobiology, Yale School of Medicine, New Haven, United StatesDepartment of Comparative Medicine and Immunobiology, Yale School of Medicine, New Haven, United States; Yale Center for Research on Aging, Yale School of Medicine, New Haven, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States; Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, United StatesAdiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects of adiponectin on promoting healthspan and lifespan remain unexplored. Here, we are using an adiponectin null mouse and a transgenic adiponectin overexpression model. We directly assessed the effects of circulating adiponectin on the aging process and found that adiponectin null mice display exacerbated age-related glucose and lipid metabolism disorders. Moreover, adiponectin null mice have a significantly shortened lifespan on both chow and high-fat diet. In contrast, a transgenic mouse model with elevated circulating adiponectin levels has a dramatically improved systemic insulin sensitivity, reduced age-related tissue inflammation and fibrosis, and a prolonged healthspan and median lifespan. These results support a role of adiponectin as an essential regulator for healthspan and lifespan.https://elifesciences.org/articles/65108Adiponectinlongevityhealthspanmetabolismfat tissue |
spellingShingle | Na Li Shangang Zhao Zhuzhen Zhang Yi Zhu Christy M Gliniak Lavanya Vishvanath Yu A An May-yun Wang Yingfeng Deng Qingzhang Zhu Bo Shan Amber Sherwood Toshiharu Onodera Orhan K Oz Ruth Gordillo Rana K Gupta Ming Liu Tamas L Horvath Vishwa Deep Dixit Philipp E Scherer Adiponectin preserves metabolic fitness during aging eLife Adiponectin longevity healthspan metabolism fat tissue |
title | Adiponectin preserves metabolic fitness during aging |
title_full | Adiponectin preserves metabolic fitness during aging |
title_fullStr | Adiponectin preserves metabolic fitness during aging |
title_full_unstemmed | Adiponectin preserves metabolic fitness during aging |
title_short | Adiponectin preserves metabolic fitness during aging |
title_sort | adiponectin preserves metabolic fitness during aging |
topic | Adiponectin longevity healthspan metabolism fat tissue |
url | https://elifesciences.org/articles/65108 |
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