Adiponectin preserves metabolic fitness during aging

Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects of adiponectin on promoting healthspan and lifespa...

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Main Authors: Na Li, Shangang Zhao, Zhuzhen Zhang, Yi Zhu, Christy M Gliniak, Lavanya Vishvanath, Yu A An, May-yun Wang, Yingfeng Deng, Qingzhang Zhu, Bo Shan, Amber Sherwood, Toshiharu Onodera, Orhan K Oz, Ruth Gordillo, Rana K Gupta, Ming Liu, Tamas L Horvath, Vishwa Deep Dixit, Philipp E Scherer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/65108
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author Na Li
Shangang Zhao
Zhuzhen Zhang
Yi Zhu
Christy M Gliniak
Lavanya Vishvanath
Yu A An
May-yun Wang
Yingfeng Deng
Qingzhang Zhu
Bo Shan
Amber Sherwood
Toshiharu Onodera
Orhan K Oz
Ruth Gordillo
Rana K Gupta
Ming Liu
Tamas L Horvath
Vishwa Deep Dixit
Philipp E Scherer
author_facet Na Li
Shangang Zhao
Zhuzhen Zhang
Yi Zhu
Christy M Gliniak
Lavanya Vishvanath
Yu A An
May-yun Wang
Yingfeng Deng
Qingzhang Zhu
Bo Shan
Amber Sherwood
Toshiharu Onodera
Orhan K Oz
Ruth Gordillo
Rana K Gupta
Ming Liu
Tamas L Horvath
Vishwa Deep Dixit
Philipp E Scherer
author_sort Na Li
collection DOAJ
description Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects of adiponectin on promoting healthspan and lifespan remain unexplored. Here, we are using an adiponectin null mouse and a transgenic adiponectin overexpression model. We directly assessed the effects of circulating adiponectin on the aging process and found that adiponectin null mice display exacerbated age-related glucose and lipid metabolism disorders. Moreover, adiponectin null mice have a significantly shortened lifespan on both chow and high-fat diet. In contrast, a transgenic mouse model with elevated circulating adiponectin levels has a dramatically improved systemic insulin sensitivity, reduced age-related tissue inflammation and fibrosis, and a prolonged healthspan and median lifespan. These results support a role of adiponectin as an essential regulator for healthspan and lifespan.
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spelling doaj.art-cc9c31e77b504b8e89c7e9bde51878cd2022-12-22T03:52:00ZengeLife Sciences Publications LtdeLife2050-084X2021-04-011010.7554/eLife.65108Adiponectin preserves metabolic fitness during agingNa Li0https://orcid.org/0000-0002-0604-6312Shangang Zhao1https://orcid.org/0000-0002-9209-8206Zhuzhen Zhang2https://orcid.org/0000-0001-6787-3920Yi Zhu3Christy M Gliniak4Lavanya Vishvanath5Yu A An6https://orcid.org/0000-0002-9678-3382May-yun Wang7Yingfeng Deng8https://orcid.org/0000-0003-1314-5105Qingzhang Zhu9Bo Shan10Amber Sherwood11Toshiharu Onodera12https://orcid.org/0000-0002-4439-0077Orhan K Oz13Ruth Gordillo14Rana K Gupta15https://orcid.org/0000-0002-9001-4531Ming Liu16https://orcid.org/0000-0003-2665-4072Tamas L Horvath17https://orcid.org/0000-0002-7522-4602Vishwa Deep Dixit18https://orcid.org/0000-0002-5341-6494Philipp E Scherer19https://orcid.org/0000-0003-0680-3392Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States; Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, ChinaTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United StatesDepartment of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Comparative Medicine and Immunobiology, Yale School of Medicine, New Haven, United StatesDepartment of Comparative Medicine and Immunobiology, Yale School of Medicine, New Haven, United States; Yale Center for Research on Aging, Yale School of Medicine, New Haven, United StatesTouchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, United States; Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, United StatesAdiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects of adiponectin on promoting healthspan and lifespan remain unexplored. Here, we are using an adiponectin null mouse and a transgenic adiponectin overexpression model. We directly assessed the effects of circulating adiponectin on the aging process and found that adiponectin null mice display exacerbated age-related glucose and lipid metabolism disorders. Moreover, adiponectin null mice have a significantly shortened lifespan on both chow and high-fat diet. In contrast, a transgenic mouse model with elevated circulating adiponectin levels has a dramatically improved systemic insulin sensitivity, reduced age-related tissue inflammation and fibrosis, and a prolonged healthspan and median lifespan. These results support a role of adiponectin as an essential regulator for healthspan and lifespan.https://elifesciences.org/articles/65108Adiponectinlongevityhealthspanmetabolismfat tissue
spellingShingle Na Li
Shangang Zhao
Zhuzhen Zhang
Yi Zhu
Christy M Gliniak
Lavanya Vishvanath
Yu A An
May-yun Wang
Yingfeng Deng
Qingzhang Zhu
Bo Shan
Amber Sherwood
Toshiharu Onodera
Orhan K Oz
Ruth Gordillo
Rana K Gupta
Ming Liu
Tamas L Horvath
Vishwa Deep Dixit
Philipp E Scherer
Adiponectin preserves metabolic fitness during aging
eLife
Adiponectin
longevity
healthspan
metabolism
fat tissue
title Adiponectin preserves metabolic fitness during aging
title_full Adiponectin preserves metabolic fitness during aging
title_fullStr Adiponectin preserves metabolic fitness during aging
title_full_unstemmed Adiponectin preserves metabolic fitness during aging
title_short Adiponectin preserves metabolic fitness during aging
title_sort adiponectin preserves metabolic fitness during aging
topic Adiponectin
longevity
healthspan
metabolism
fat tissue
url https://elifesciences.org/articles/65108
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