Anti-Proliferative Activity and Tubulin Targeting of Novel Micro and Nanoparticles Complexes of 4-Amino-3-Thion-1, 2, 4-Triazole Derivatives
In this study, novel micro and nanoparticle complexes of Ag(Ⅰ), Ni(Ⅱ), and Pd(Ⅱ) ion with new asymmetrical Schiff base triazole ligand (4-(((3-mercapto-5-(naphthalen-1-ylmethyl)-4H-1, 2, 4-triazol-4-yl)imino)methyl)phenol) were prepared. The Schiff base micro complexes were identified using Fourier-...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2020-03-01
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| Series: | Nano Biomedicine and Engineering |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.5101/nbe.v12i1.p75-89 |
| _version_ | 1797673403233075200 |
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| author | Atheer Ali Rehab Al-Hassani Dhia Hussain Majid Jabir Hamid Meteab |
| author_facet | Atheer Ali Rehab Al-Hassani Dhia Hussain Majid Jabir Hamid Meteab |
| author_sort | Atheer Ali |
| collection | DOAJ |
| description | In this study, novel micro and nanoparticle complexes of Ag(Ⅰ), Ni(Ⅱ), and Pd(Ⅱ) ion with new asymmetrical Schiff base triazole ligand (4-(((3-mercapto-5-(naphthalen-1-ylmethyl)-4H-1, 2, 4-triazol-4-yl)imino)methyl)phenol) were prepared. The Schiff base micro complexes were identified using Fourier-transform infrared spectroscopy (FTIR), Ultraviolet–visible spectroscopy (UV-Vis), flame atomic absorption, elemental analysis C.H.N.S, conductivity measurements and magnetic susceptibility. New nanoparticles Schiff base triazole ligand (4-(((3-mercapto-5-(naphthalen-1-ylmethyl)-4H-1, 2, 4-triazol-4-yl)imino)methyl)phenol) ligand and Ag(Ⅰ), Ni(Ⅱ) and Pd(Ⅱ) complexes were synthesized as a novel compounds by using sonication method, and were fully characterized by using FTIR, atomic force microscopy (AFM), scanning electron microscope (SEM), and X-ray powder diffraction (XRD). The antioxidant activity of tested compounds was tested using DPPH assay. The effect of synthetic novel compounds on cancer cell line MCF-7 proliferation was measured by MTT assay. The ability of synthetic novel compounds in induction of apotosis was achieved using acridine orange/ethidium bromide (AO/EB) stains. We found that the synthetic novel compounds had the potential to inhibit growth of cancer cell at low concentrations. The effect of synthetic compounds on cell growth and proliferation of MCF-7 cells was associated with cell cycle arrest, and increased apoptosis. Our results showed that the synthetic novel compounds inhibited cancer cell line proliferation with a mechanism of action similar to that of other tubulin inhibitors. In conclusion, the results of this study indicate that synthetic novel compounds represent a new chemo type with a novel mechanisms of action and that it has the potential to be developed for tumor therapy. |
| first_indexed | 2024-03-11T21:43:59Z |
| format | Article |
| id | doaj.art-cc9efe132bde4ea6b0de4b82afcc38a3 |
| institution | Directory Open Access Journal |
| issn | 2150-5578 |
| language | English |
| last_indexed | 2024-03-11T21:43:59Z |
| publishDate | 2020-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Nano Biomedicine and Engineering |
| spelling | doaj.art-cc9efe132bde4ea6b0de4b82afcc38a32023-09-26T11:03:54ZengTsinghua University PressNano Biomedicine and Engineering2150-55782020-03-01121758910.5101/nbe.v12i1.p75-89Anti-Proliferative Activity and Tubulin Targeting of Novel Micro and Nanoparticles Complexes of 4-Amino-3-Thion-1, 2, 4-Triazole DerivativesAtheer Ali0Rehab Al-Hassani1Dhia Hussain2Majid Jabir3Hamid Meteab4Department of Chemistry, College of Science, Al-Mustansyah University, Baghdad, IraqDepartment of Chemistry, College of Science, Al-Mustansyah University, Baghdad, IraqDepartment of Chemistry, College of Science, Al-Mustansyah University, Baghdad, IraqDivision of Biotechnology, Department of Applied Science, University of Technology, Baghdad, IraqMinistry of Higher Education and Scientific Research, IraqIn this study, novel micro and nanoparticle complexes of Ag(Ⅰ), Ni(Ⅱ), and Pd(Ⅱ) ion with new asymmetrical Schiff base triazole ligand (4-(((3-mercapto-5-(naphthalen-1-ylmethyl)-4H-1, 2, 4-triazol-4-yl)imino)methyl)phenol) were prepared. The Schiff base micro complexes were identified using Fourier-transform infrared spectroscopy (FTIR), Ultraviolet–visible spectroscopy (UV-Vis), flame atomic absorption, elemental analysis C.H.N.S, conductivity measurements and magnetic susceptibility. New nanoparticles Schiff base triazole ligand (4-(((3-mercapto-5-(naphthalen-1-ylmethyl)-4H-1, 2, 4-triazol-4-yl)imino)methyl)phenol) ligand and Ag(Ⅰ), Ni(Ⅱ) and Pd(Ⅱ) complexes were synthesized as a novel compounds by using sonication method, and were fully characterized by using FTIR, atomic force microscopy (AFM), scanning electron microscope (SEM), and X-ray powder diffraction (XRD). The antioxidant activity of tested compounds was tested using DPPH assay. The effect of synthetic novel compounds on cancer cell line MCF-7 proliferation was measured by MTT assay. The ability of synthetic novel compounds in induction of apotosis was achieved using acridine orange/ethidium bromide (AO/EB) stains. We found that the synthetic novel compounds had the potential to inhibit growth of cancer cell at low concentrations. The effect of synthetic compounds on cell growth and proliferation of MCF-7 cells was associated with cell cycle arrest, and increased apoptosis. Our results showed that the synthetic novel compounds inhibited cancer cell line proliferation with a mechanism of action similar to that of other tubulin inhibitors. In conclusion, the results of this study indicate that synthetic novel compounds represent a new chemo type with a novel mechanisms of action and that it has the potential to be developed for tumor therapy.https://www.sciopen.com/article/10.5101/nbe.v12i1.p75-89schiff base triazolenanoparticle complexesdpphanti-proliferativetubulin targeting |
| spellingShingle | Atheer Ali Rehab Al-Hassani Dhia Hussain Majid Jabir Hamid Meteab Anti-Proliferative Activity and Tubulin Targeting of Novel Micro and Nanoparticles Complexes of 4-Amino-3-Thion-1, 2, 4-Triazole Derivatives Nano Biomedicine and Engineering schiff base triazole nanoparticle complexes dpph anti-proliferative tubulin targeting |
| title | Anti-Proliferative Activity and Tubulin Targeting of Novel Micro and Nanoparticles Complexes of 4-Amino-3-Thion-1, 2, 4-Triazole Derivatives |
| title_full | Anti-Proliferative Activity and Tubulin Targeting of Novel Micro and Nanoparticles Complexes of 4-Amino-3-Thion-1, 2, 4-Triazole Derivatives |
| title_fullStr | Anti-Proliferative Activity and Tubulin Targeting of Novel Micro and Nanoparticles Complexes of 4-Amino-3-Thion-1, 2, 4-Triazole Derivatives |
| title_full_unstemmed | Anti-Proliferative Activity and Tubulin Targeting of Novel Micro and Nanoparticles Complexes of 4-Amino-3-Thion-1, 2, 4-Triazole Derivatives |
| title_short | Anti-Proliferative Activity and Tubulin Targeting of Novel Micro and Nanoparticles Complexes of 4-Amino-3-Thion-1, 2, 4-Triazole Derivatives |
| title_sort | anti proliferative activity and tubulin targeting of novel micro and nanoparticles complexes of 4 amino 3 thion 1 2 4 triazole derivatives |
| topic | schiff base triazole nanoparticle complexes dpph anti-proliferative tubulin targeting |
| url | https://www.sciopen.com/article/10.5101/nbe.v12i1.p75-89 |
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