Microvascular Tissue Engineering—A Review
Tissue engineering and regenerative medicine have come a long way in recent decades, but the lack of functioning vasculature is still a major obstacle preventing the development of thicker, physiologically relevant tissue constructs. A large part of this obstacle lies in the development of the vesse...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/9/6/589 |
| _version_ | 1797533169208000512 |
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| author | Jernej Vajda Marko Milojević Uroš Maver Boštjan Vihar |
| author_facet | Jernej Vajda Marko Milojević Uroš Maver Boštjan Vihar |
| author_sort | Jernej Vajda |
| collection | DOAJ |
| description | Tissue engineering and regenerative medicine have come a long way in recent decades, but the lack of functioning vasculature is still a major obstacle preventing the development of thicker, physiologically relevant tissue constructs. A large part of this obstacle lies in the development of the vessels on a microscale—the microvasculature—that are crucial for oxygen and nutrient delivery. In this review, we present the state of the art in the field of microvascular tissue engineering and demonstrate the challenges for future research in various sections of the field. Finally, we illustrate the potential strategies for addressing some of those challenges. |
| first_indexed | 2024-03-10T11:10:41Z |
| format | Article |
| id | doaj.art-cc9f57faf4fb47da964120dcc5761bde |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T11:10:41Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-cc9f57faf4fb47da964120dcc5761bde2023-11-21T20:48:27ZengMDPI AGBiomedicines2227-90592021-05-019658910.3390/biomedicines9060589Microvascular Tissue Engineering—A ReviewJernej Vajda0Marko Milojević1Uroš Maver2Boštjan Vihar3Faculty of Medicine, Institute of Biomedical Sciences, University of Maribor, Taborska ulica 8, 2000 Maribor, SloveniaFaculty of Medicine, Institute of Biomedical Sciences, University of Maribor, Taborska ulica 8, 2000 Maribor, SloveniaFaculty of Medicine, Institute of Biomedical Sciences, University of Maribor, Taborska ulica 8, 2000 Maribor, SloveniaFaculty of Medicine, Institute of Biomedical Sciences, University of Maribor, Taborska ulica 8, 2000 Maribor, SloveniaTissue engineering and regenerative medicine have come a long way in recent decades, but the lack of functioning vasculature is still a major obstacle preventing the development of thicker, physiologically relevant tissue constructs. A large part of this obstacle lies in the development of the vessels on a microscale—the microvasculature—that are crucial for oxygen and nutrient delivery. In this review, we present the state of the art in the field of microvascular tissue engineering and demonstrate the challenges for future research in various sections of the field. Finally, we illustrate the potential strategies for addressing some of those challenges.https://www.mdpi.com/2227-9059/9/6/589regenerative medicinetissue engineeringvascularizationbiomaterialsmicrovascularizationcoculture |
| spellingShingle | Jernej Vajda Marko Milojević Uroš Maver Boštjan Vihar Microvascular Tissue Engineering—A Review Biomedicines regenerative medicine tissue engineering vascularization biomaterials microvascularization coculture |
| title | Microvascular Tissue Engineering—A Review |
| title_full | Microvascular Tissue Engineering—A Review |
| title_fullStr | Microvascular Tissue Engineering—A Review |
| title_full_unstemmed | Microvascular Tissue Engineering—A Review |
| title_short | Microvascular Tissue Engineering—A Review |
| title_sort | microvascular tissue engineering a review |
| topic | regenerative medicine tissue engineering vascularization biomaterials microvascularization coculture |
| url | https://www.mdpi.com/2227-9059/9/6/589 |
| work_keys_str_mv | AT jernejvajda microvasculartissueengineeringareview AT markomilojevic microvasculartissueengineeringareview AT urosmaver microvasculartissueengineeringareview AT bostjanvihar microvasculartissueengineeringareview |