Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions
LGN and NuMA link epithelial polarity sites with astral microtubules and associate with dynein, but the architecture of such cortical force-generating complexes is unknown. Here, the authors report the crystal structure of NuMA:LGN hetero-hexamers, and unveil their role in promoting the assembly of...
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Bibliographic Details
| Main Authors: |
Laura Pirovano,
Simone Culurgioni,
Manuel Carminati,
Andrea Alfieri,
Silvia Monzani,
Valentina Cecatiello,
Chiara Gaddoni,
Francesca Rizzelli,
James Foadi,
Sebastiano Pasqualato,
Marina Mapelli |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2019-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-09999-w
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