Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions
LGN and NuMA link epithelial polarity sites with astral microtubules and associate with dynein, but the architecture of such cortical force-generating complexes is unknown. Here, the authors report the crystal structure of NuMA:LGN hetero-hexamers, and unveil their role in promoting the assembly of...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09999-w |
| _version_ | 1818834985242591232 |
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| author | Laura Pirovano Simone Culurgioni Manuel Carminati Andrea Alfieri Silvia Monzani Valentina Cecatiello Chiara Gaddoni Francesca Rizzelli James Foadi Sebastiano Pasqualato Marina Mapelli |
| author_facet | Laura Pirovano Simone Culurgioni Manuel Carminati Andrea Alfieri Silvia Monzani Valentina Cecatiello Chiara Gaddoni Francesca Rizzelli James Foadi Sebastiano Pasqualato Marina Mapelli |
| author_sort | Laura Pirovano |
| collection | DOAJ |
| description | LGN and NuMA link epithelial polarity sites with astral microtubules and associate with dynein, but the architecture of such cortical force-generating complexes is unknown. Here, the authors report the crystal structure of NuMA:LGN hetero-hexamers, and unveil their role in promoting the assembly of active cortical dynein/dynactin motors. |
| first_indexed | 2024-12-19T02:43:31Z |
| format | Article |
| id | doaj.art-cca2029813694381ba0884810c0da218 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T02:43:31Z |
| publishDate | 2019-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-cca2029813694381ba0884810c0da2182022-12-21T20:39:03ZengNature PortfolioNature Communications2041-17232019-05-0110111410.1038/s41467-019-09999-wHexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisionsLaura Pirovano0Simone Culurgioni1Manuel Carminati2Andrea Alfieri3Silvia Monzani4Valentina Cecatiello5Chiara Gaddoni6Francesca Rizzelli7James Foadi8Sebastiano Pasqualato9Marina Mapelli10IEO, European Institute of Oncology IRCCSIEO, European Institute of Oncology IRCCSIEO, European Institute of Oncology IRCCSIEO, European Institute of Oncology IRCCSIEO, European Institute of Oncology IRCCSIEO, European Institute of Oncology IRCCSIEO, European Institute of Oncology IRCCSIEO, European Institute of Oncology IRCCSDepartment of Mathematical Sciences, University of BathIEO, European Institute of Oncology IRCCSIEO, European Institute of Oncology IRCCSLGN and NuMA link epithelial polarity sites with astral microtubules and associate with dynein, but the architecture of such cortical force-generating complexes is unknown. Here, the authors report the crystal structure of NuMA:LGN hetero-hexamers, and unveil their role in promoting the assembly of active cortical dynein/dynactin motors.https://doi.org/10.1038/s41467-019-09999-w |
| spellingShingle | Laura Pirovano Simone Culurgioni Manuel Carminati Andrea Alfieri Silvia Monzani Valentina Cecatiello Chiara Gaddoni Francesca Rizzelli James Foadi Sebastiano Pasqualato Marina Mapelli Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions Nature Communications |
| title | Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions |
| title_full | Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions |
| title_fullStr | Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions |
| title_full_unstemmed | Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions |
| title_short | Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions |
| title_sort | hexameric numa lgn structures promote multivalent interactions required for planar epithelial divisions |
| url | https://doi.org/10.1038/s41467-019-09999-w |
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