Prognostic value of PaO/FiO, SOFA and D-dimer in elderly patients with sepsis
Objective To investigate the prognostic value for predicting mortality of partial pressure of oxygen/fraction of inspired oxygen (PaO 2 /FiO 2 ), the Sequential Organ Failure Assessment (SOFA) score and D-dimer in elderly patients with sepsis. Methods This retrospective cohort study enrolled elderly...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-06-01
|
| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605221100755 |
| _version_ | 1818216478518804480 |
|---|---|
| author | Tao Li Wan-Qin Hu Xian Li Jia-Peng Zhang Li-Zhi Tan Li-Xia Yu Hai-Rong Gu Ze-Ya Shi |
| author_facet | Tao Li Wan-Qin Hu Xian Li Jia-Peng Zhang Li-Zhi Tan Li-Xia Yu Hai-Rong Gu Ze-Ya Shi |
| author_sort | Tao Li |
| collection | DOAJ |
| description | Objective To investigate the prognostic value for predicting mortality of partial pressure of oxygen/fraction of inspired oxygen (PaO 2 /FiO 2 ), the Sequential Organ Failure Assessment (SOFA) score and D-dimer in elderly patients with sepsis. Methods This retrospective cohort study enrolled elderly patients with sepsis admitted to the intensive care unit (ICU) between January 2019 and October 2020. Patients were divided into a survival group and a non-survival group. Biomarkers, SOFA, Acute Physiology and Chronic Health Evaluation II and Glasgow Coma Scale scores were recorded within 24 h after admission to the ICU. Results A total of 135 elderly patients with sepsis were enrolled in the study: 89 were in the survival group and 46 were in the non-survival group at 28 days. Univariate and multivariate regression analyses demonstrated that PaO 2 /FiO 2 , SOFA and D-dimer were independently associated with 28-day mortality. The predictive performance for mortality of the combination of PaO 2 /FiO 2 , SOFA score and D-dimer (area under the receiver operating characteristic curve of 0.926) was higher than the values for the individual factors (0.761, 0.745 and 0.878, respectively). Conclusion The combination of PaO 2 /FiO 2 , SOFA score and D-dimer represents a promising tool and biomarker for predicting 28-day mortality of the elderly patients with sepsis. |
| first_indexed | 2024-12-12T06:52:37Z |
| format | Article |
| id | doaj.art-cca31070fe174c88b2130abeb8b0a6b7 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-12T06:52:37Z |
| publishDate | 2022-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-cca31070fe174c88b2130abeb8b0a6b72022-12-22T00:34:02ZengSAGE PublishingJournal of International Medical Research1473-23002022-06-015010.1177/03000605221100755Prognostic value of PaO/FiO, SOFA and D-dimer in elderly patients with sepsisTao LiWan-Qin HuXian LiJia-Peng ZhangLi-Zhi TanLi-Xia YuHai-Rong GuZe-Ya ShiObjective To investigate the prognostic value for predicting mortality of partial pressure of oxygen/fraction of inspired oxygen (PaO 2 /FiO 2 ), the Sequential Organ Failure Assessment (SOFA) score and D-dimer in elderly patients with sepsis. Methods This retrospective cohort study enrolled elderly patients with sepsis admitted to the intensive care unit (ICU) between January 2019 and October 2020. Patients were divided into a survival group and a non-survival group. Biomarkers, SOFA, Acute Physiology and Chronic Health Evaluation II and Glasgow Coma Scale scores were recorded within 24 h after admission to the ICU. Results A total of 135 elderly patients with sepsis were enrolled in the study: 89 were in the survival group and 46 were in the non-survival group at 28 days. Univariate and multivariate regression analyses demonstrated that PaO 2 /FiO 2 , SOFA and D-dimer were independently associated with 28-day mortality. The predictive performance for mortality of the combination of PaO 2 /FiO 2 , SOFA score and D-dimer (area under the receiver operating characteristic curve of 0.926) was higher than the values for the individual factors (0.761, 0.745 and 0.878, respectively). Conclusion The combination of PaO 2 /FiO 2 , SOFA score and D-dimer represents a promising tool and biomarker for predicting 28-day mortality of the elderly patients with sepsis.https://doi.org/10.1177/03000605221100755 |
| spellingShingle | Tao Li Wan-Qin Hu Xian Li Jia-Peng Zhang Li-Zhi Tan Li-Xia Yu Hai-Rong Gu Ze-Ya Shi Prognostic value of PaO/FiO, SOFA and D-dimer in elderly patients with sepsis Journal of International Medical Research |
| title | Prognostic value of PaO/FiO, SOFA and D-dimer in elderly patients with sepsis |
| title_full | Prognostic value of PaO/FiO, SOFA and D-dimer in elderly patients with sepsis |
| title_fullStr | Prognostic value of PaO/FiO, SOFA and D-dimer in elderly patients with sepsis |
| title_full_unstemmed | Prognostic value of PaO/FiO, SOFA and D-dimer in elderly patients with sepsis |
| title_short | Prognostic value of PaO/FiO, SOFA and D-dimer in elderly patients with sepsis |
| title_sort | prognostic value of pao fio sofa and d dimer in elderly patients with sepsis |
| url | https://doi.org/10.1177/03000605221100755 |
| work_keys_str_mv | AT taoli prognosticvalueofpaofiosofaandddimerinelderlypatientswithsepsis AT wanqinhu prognosticvalueofpaofiosofaandddimerinelderlypatientswithsepsis AT xianli prognosticvalueofpaofiosofaandddimerinelderlypatientswithsepsis AT jiapengzhang prognosticvalueofpaofiosofaandddimerinelderlypatientswithsepsis AT lizhitan prognosticvalueofpaofiosofaandddimerinelderlypatientswithsepsis AT lixiayu prognosticvalueofpaofiosofaandddimerinelderlypatientswithsepsis AT haironggu prognosticvalueofpaofiosofaandddimerinelderlypatientswithsepsis AT zeyashi prognosticvalueofpaofiosofaandddimerinelderlypatientswithsepsis |