Polysubstance use disorder as a probable self-medication in Isaacs’ syndrome
Isaacs’ syndrome (IS) is an autoimmunological hyperexcitability syndrome of the peripheral motor nerves, manifesting with progressive muscle stiffness, involuntary continuous muscle twitching, muscle pain and cramping, sweating, and decreased reflexes. We report a 31-year-old man who was suffering f...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
AVES
2018-01-01
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| Series: | Psychiatry and Clinical Psychopharmacology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/24750573.2017.1389627 |
| _version_ | 1797919890416336896 |
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| author | Yasin Hasan Balcioglu Simge Seren Kirlioglu Pinar Cetinay Aydin |
| author_facet | Yasin Hasan Balcioglu Simge Seren Kirlioglu Pinar Cetinay Aydin |
| author_sort | Yasin Hasan Balcioglu |
| collection | DOAJ |
| description | Isaacs’ syndrome (IS) is an autoimmunological hyperexcitability syndrome of the peripheral motor nerves, manifesting with progressive muscle stiffness, involuntary continuous muscle twitching, muscle pain and cramping, sweating, and decreased reflexes. We report a 31-year-old man who was suffering from muscle twitches and stiffness in lower extremities and previously diagnosed with IS in his age of 16 through electrophysiological studies and the shown presence of autoantibodies against voltage-gated potassium channels. Without any adherence to the prescribed treatment, he had been using synthetic cannabinoids and opioids for 10 years. He admitted lessened complaints by using them. Current literature offered cannabinoid receptor agonists not only for symptomatic relief in IS, but also potential modulator effects on both potassium channels and autoimmunity. Opioids were also recognized with their analgesic and antispastic effects in the management of IS. This report aimed to discuss possible medicinal effects and therapeutic mechanisms of aforementioned psychoactive molecules on the symptomatology of IS. |
| first_indexed | 2024-04-10T13:53:33Z |
| format | Article |
| id | doaj.art-cca33c1ca21546428fbbc356d8d34b6f |
| institution | Directory Open Access Journal |
| issn | 2475-0573 2475-0581 |
| language | English |
| last_indexed | 2024-04-10T13:53:33Z |
| publishDate | 2018-01-01 |
| publisher | AVES |
| record_format | Article |
| series | Psychiatry and Clinical Psychopharmacology |
| spelling | doaj.art-cca33c1ca21546428fbbc356d8d34b6f2023-02-15T16:10:37ZengAVESPsychiatry and Clinical Psychopharmacology2475-05732475-05812018-01-0128111611810.1080/24750573.2017.13896271389627Polysubstance use disorder as a probable self-medication in Isaacs’ syndromeYasin Hasan Balcioglu0Simge Seren Kirlioglu1Pinar Cetinay Aydin2Bakirkoy Prof Mazhar Osman Training and Research Hospital for Psychiatry, Neurology and NeurosurgeryBakirkoy Prof Mazhar Osman Training and Research Hospital for Psychiatry, Neurology and NeurosurgeryBakirkoy Prof Mazhar Osman Training and Research Hospital for Psychiatry, Neurology and NeurosurgeryIsaacs’ syndrome (IS) is an autoimmunological hyperexcitability syndrome of the peripheral motor nerves, manifesting with progressive muscle stiffness, involuntary continuous muscle twitching, muscle pain and cramping, sweating, and decreased reflexes. We report a 31-year-old man who was suffering from muscle twitches and stiffness in lower extremities and previously diagnosed with IS in his age of 16 through electrophysiological studies and the shown presence of autoantibodies against voltage-gated potassium channels. Without any adherence to the prescribed treatment, he had been using synthetic cannabinoids and opioids for 10 years. He admitted lessened complaints by using them. Current literature offered cannabinoid receptor agonists not only for symptomatic relief in IS, but also potential modulator effects on both potassium channels and autoimmunity. Opioids were also recognized with their analgesic and antispastic effects in the management of IS. This report aimed to discuss possible medicinal effects and therapeutic mechanisms of aforementioned psychoactive molecules on the symptomatology of IS.http://dx.doi.org/10.1080/24750573.2017.1389627CannabinoidsIsaacs’ syndromeneuromyotoniaopioidssubstance use disorder |
| spellingShingle | Yasin Hasan Balcioglu Simge Seren Kirlioglu Pinar Cetinay Aydin Polysubstance use disorder as a probable self-medication in Isaacs’ syndrome Psychiatry and Clinical Psychopharmacology Cannabinoids Isaacs’ syndrome neuromyotonia opioids substance use disorder |
| title | Polysubstance use disorder as a probable self-medication in Isaacs’ syndrome |
| title_full | Polysubstance use disorder as a probable self-medication in Isaacs’ syndrome |
| title_fullStr | Polysubstance use disorder as a probable self-medication in Isaacs’ syndrome |
| title_full_unstemmed | Polysubstance use disorder as a probable self-medication in Isaacs’ syndrome |
| title_short | Polysubstance use disorder as a probable self-medication in Isaacs’ syndrome |
| title_sort | polysubstance use disorder as a probable self medication in isaacs syndrome |
| topic | Cannabinoids Isaacs’ syndrome neuromyotonia opioids substance use disorder |
| url | http://dx.doi.org/10.1080/24750573.2017.1389627 |
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