The effect of lidocaine on reducing the tracheal mucosal damage following tracheal intubation
Background: The aim of this study was to investigate the efficacy of lidocaine solution in the cuff of the endotracheal tube in reducing mucosal damage following tracheal intubation. Materials and Methods: This was a randomized controlled trial study undertaken in the intensive care unit patients. P...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Journal of Research in Medical Sciences |
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| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=9;spage=733;epage=738;aulast=Abbasi |
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| author | Saeed Abbasi Hosein Mahjobipoor Parviz Kashefi Gholamreza Massumi Omid Aghadavoudi Ziba Farajzadegan Parvin Sajedi |
| author_facet | Saeed Abbasi Hosein Mahjobipoor Parviz Kashefi Gholamreza Massumi Omid Aghadavoudi Ziba Farajzadegan Parvin Sajedi |
| author_sort | Saeed Abbasi |
| collection | DOAJ |
| description | Background: The aim of this study was to investigate the efficacy of lidocaine solution in the cuff of the endotracheal tube in reducing mucosal damage following tracheal intubation. Materials and Methods: This was a randomized controlled trial study undertaken in the intensive care unit patients. Participants, who met all eligibility criteria, were randomly assigned to one of two groups of patients, according to whether lidocaine or air was used to fill the tracheal tube cuff. The tracheal mucosa at the site of cuff inflation was inspected by fiberoptic bronchoscopy and scored at the 24 h and 48 h after intubation. Results: In all, 51 patients (26 patients in the lidocaine group and 25 patients in the control group) completed the study. After 24 h, erythema and/or edema of tracheal mucosa were seen in 2 patients (7.7%) of lidocaine group and 6 patients (24%) of air group (P = 0.109). Binary logistic regression analysis showed that lidocaine has a significant protective effect against mucosal damage (odds ratio = 0.72, confidence interval = 0.60-0.87). Conclusion: The inflation of the tracheal tube cuff with lidocaine was superior to air in decreasing the incidence of mucosal damage in the 24 h and 48 h post intubation. |
| first_indexed | 2024-12-10T22:17:47Z |
| format | Article |
| id | doaj.art-cca4da27dcfc4ff58e2cf341d4fa2617 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-10T22:17:47Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-cca4da27dcfc4ff58e2cf341d4fa26172022-12-22T01:31:25ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362013-01-01189733738The effect of lidocaine on reducing the tracheal mucosal damage following tracheal intubationSaeed AbbasiHosein MahjobipoorParviz KashefiGholamreza MassumiOmid AghadavoudiZiba FarajzadeganParvin SajediBackground: The aim of this study was to investigate the efficacy of lidocaine solution in the cuff of the endotracheal tube in reducing mucosal damage following tracheal intubation. Materials and Methods: This was a randomized controlled trial study undertaken in the intensive care unit patients. Participants, who met all eligibility criteria, were randomly assigned to one of two groups of patients, according to whether lidocaine or air was used to fill the tracheal tube cuff. The tracheal mucosa at the site of cuff inflation was inspected by fiberoptic bronchoscopy and scored at the 24 h and 48 h after intubation. Results: In all, 51 patients (26 patients in the lidocaine group and 25 patients in the control group) completed the study. After 24 h, erythema and/or edema of tracheal mucosa were seen in 2 patients (7.7%) of lidocaine group and 6 patients (24%) of air group (P = 0.109). Binary logistic regression analysis showed that lidocaine has a significant protective effect against mucosal damage (odds ratio = 0.72, confidence interval = 0.60-0.87). Conclusion: The inflation of the tracheal tube cuff with lidocaine was superior to air in decreasing the incidence of mucosal damage in the 24 h and 48 h post intubation.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=9;spage=733;epage=738;aulast=AbbasiIntubationlidocainemechanical ventilationmucosal damage |
| spellingShingle | Saeed Abbasi Hosein Mahjobipoor Parviz Kashefi Gholamreza Massumi Omid Aghadavoudi Ziba Farajzadegan Parvin Sajedi The effect of lidocaine on reducing the tracheal mucosal damage following tracheal intubation Journal of Research in Medical Sciences Intubation lidocaine mechanical ventilation mucosal damage |
| title | The effect of lidocaine on reducing the tracheal mucosal damage following tracheal intubation |
| title_full | The effect of lidocaine on reducing the tracheal mucosal damage following tracheal intubation |
| title_fullStr | The effect of lidocaine on reducing the tracheal mucosal damage following tracheal intubation |
| title_full_unstemmed | The effect of lidocaine on reducing the tracheal mucosal damage following tracheal intubation |
| title_short | The effect of lidocaine on reducing the tracheal mucosal damage following tracheal intubation |
| title_sort | effect of lidocaine on reducing the tracheal mucosal damage following tracheal intubation |
| topic | Intubation lidocaine mechanical ventilation mucosal damage |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=9;spage=733;epage=738;aulast=Abbasi |
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