GABA-A Alpha 2/3 but Not Alpha 1 Receptor Subunit Ligand Inhibits Harmaline and Pimozide-Induced Tremor in Rats

GABA-A Alpha 2/3 but Not Alpha 1 Receptor Subunit Ligand Inhibits Harmaline and Pimozide-Induced Tremor in Rats

Treatment of tremors, such as in essential tremor (ET) and Parkinson’s disease (PD) is mostly ineffective. Exact tremor pathomechanisms are unknown and relevant animal models are missing. GABA-A receptor is a target for tremorolytic medications, but current non-selective drugs produce side effects a...

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Bibliographic Details
Main Authors: Barbara Kosmowska, Martyna Paleczna, Dominika Biała, Justyna Kadłuczka, Jadwiga Wardas, Jeffrey M. Witkin, James M. Cook, Dishary Sharmin, Monika Marcinkowska, Katarzyna Z. Kuter
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Biomolecules
Subjects:
resting tremor
action tremor
GABAA alpha 1
GABAA alpha 2/3
Parkinson’s disease
essential tremor
Online Access:https://www.mdpi.com/2218-273X/13/2/197

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https://www.mdpi.com/2218-273X/13/2/197

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