Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases
Withaferin A (WFA) was identified as the most active phytocompound of the plant <i>Withania somnifera</i> (<i>WS</i>) and as having multiple therapeutic/ameliorating properties (anticancer, antiangiogenic, anti-invasive, anti-inflammatory, proapoptotic, etc.) in case of vario...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/9/2407 |
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| author | Simona Bungau Cosmin Mihai Vesa Areha Abid Tapan Behl Delia Mirela Tit Anamaria Lavinia Purza Bianca Pasca Laura Maghiar Todan Laura Endres |
| author_facet | Simona Bungau Cosmin Mihai Vesa Areha Abid Tapan Behl Delia Mirela Tit Anamaria Lavinia Purza Bianca Pasca Laura Maghiar Todan Laura Endres |
| author_sort | Simona Bungau |
| collection | DOAJ |
| description | Withaferin A (WFA) was identified as the most active phytocompound of the plant <i>Withania somnifera</i> (<i>WS</i>) and as having multiple therapeutic/ameliorating properties (anticancer, antiangiogenic, anti-invasive, anti-inflammatory, proapoptotic, etc.) in case of various diseases. In drug chemistry, WFA in silico approaches have identified favorite biological targets, stimulating and accelerating research to evaluate its pharmacological activity—numerous anticancer effects manifested in various organs (breast, pancreas, skin, colon, etc.), antivirals, anti-infective, etc., which are not yet sufficiently explored. This paper is a synthesis of the most relevant specialized papers in the field that are focused on the use of WFA in dermatological diseases, describing its mechanism of action while providing, at the same time, details about the results of its testing in in vitro/in vivo studies. |
| first_indexed | 2024-03-10T12:07:59Z |
| format | Article |
| id | doaj.art-cca61762852740e88540b0191a89d9a3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T12:07:59Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-cca61762852740e88540b0191a89d9a32023-11-21T16:26:44ZengMDPI AGMolecules1420-30492021-04-01269240710.3390/molecules26092407Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological DiseasesSimona Bungau0Cosmin Mihai Vesa1Areha Abid2Tapan Behl3Delia Mirela Tit4Anamaria Lavinia Purza5Bianca Pasca6Laura Maghiar Todan7Laura Endres8Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, RomaniaDepartment of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, RomaniaDepartment of Food Science, Faculty of Agricultural and Food Sciences, University of Debrecen, 4032 Debrecen, HungaryDepartment of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Punjab 140401, IndiaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, RomaniaDepartment of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, RomaniaDoctoral School of Biomedical Sciences, University of Oradea, 410073 Oradea, RomaniaDepartment of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, RomaniaWithaferin A (WFA) was identified as the most active phytocompound of the plant <i>Withania somnifera</i> (<i>WS</i>) and as having multiple therapeutic/ameliorating properties (anticancer, antiangiogenic, anti-invasive, anti-inflammatory, proapoptotic, etc.) in case of various diseases. In drug chemistry, WFA in silico approaches have identified favorite biological targets, stimulating and accelerating research to evaluate its pharmacological activity—numerous anticancer effects manifested in various organs (breast, pancreas, skin, colon, etc.), antivirals, anti-infective, etc., which are not yet sufficiently explored. This paper is a synthesis of the most relevant specialized papers in the field that are focused on the use of WFA in dermatological diseases, describing its mechanism of action while providing, at the same time, details about the results of its testing in in vitro/in vivo studies.https://www.mdpi.com/1420-3049/26/9/2407<i>Withania somnifera</i>withaferin Adermatologydermatological disordersmelanomaAyurvedic medicine |
| spellingShingle | Simona Bungau Cosmin Mihai Vesa Areha Abid Tapan Behl Delia Mirela Tit Anamaria Lavinia Purza Bianca Pasca Laura Maghiar Todan Laura Endres Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases Molecules <i>Withania somnifera</i> withaferin A dermatology dermatological disorders melanoma Ayurvedic medicine |
| title | Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases |
| title_full | Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases |
| title_fullStr | Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases |
| title_full_unstemmed | Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases |
| title_short | Withaferin A—A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases |
| title_sort | withaferin a a promising phytochemical compound with multiple results in dermatological diseases |
| topic | <i>Withania somnifera</i> withaferin A dermatology dermatological disorders melanoma Ayurvedic medicine |
| url | https://www.mdpi.com/1420-3049/26/9/2407 |
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