HCV Interplay with Lipoproteins: Inside or Outside the Cells?
Hepatitis C virus (HCV) infection is a major public health issue leading to chronic liver diseases. HCV particles are unique owing to their particular lipid composition, namely the incorporation of neutral lipids and apolipoproteins. The mechanism of association between HCV virion components and the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/12/4/434 |
| _version_ | 1827718830902738944 |
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| author | François-Loïc Cosset Chloé Mialon Bertrand Boson Christelle Granier Solène Denolly |
| author_facet | François-Loïc Cosset Chloé Mialon Bertrand Boson Christelle Granier Solène Denolly |
| author_sort | François-Loïc Cosset |
| collection | DOAJ |
| description | Hepatitis C virus (HCV) infection is a major public health issue leading to chronic liver diseases. HCV particles are unique owing to their particular lipid composition, namely the incorporation of neutral lipids and apolipoproteins. The mechanism of association between HCV virion components and these lipoproteins factors remains poorly understood as well as its impact in subsequent steps of the viral life cycle, such as entry into cells. It was proposed that the lipoprotein biogenesis pathway is involved in HCV morphogenesis; yet, recent evidence indicated that HCV particles can mature and evolve biochemically in the extracellular medium after egress. In addition, several viral, cellular and blood components have been shown to influence and regulate this specific association. Finally, this specific structure and composition of HCV particles was found to influence entry into cells as well as their stability and sensitivity to neutralizing antibodies. Due to its specific particle composition, studying the association of HCV particles with lipoproteins remains an important goal towards the rational design of a protective vaccine. |
| first_indexed | 2024-03-10T20:31:23Z |
| format | Article |
| id | doaj.art-cca786944fef41e18675be78d5b5e2a0 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T20:31:23Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-cca786944fef41e18675be78d5b5e2a02023-11-19T21:24:29ZengMDPI AGViruses1999-49152020-04-0112443410.3390/v12040434HCV Interplay with Lipoproteins: Inside or Outside the Cells?François-Loïc Cosset0Chloé Mialon1Bertrand Boson2Christelle Granier3Solène Denolly4CIRI—Centre International de Recherche en Infectiologie, Univ Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, F-69007 Lyon, FranceCIRI—Centre International de Recherche en Infectiologie, Univ Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, F-69007 Lyon, FranceCIRI—Centre International de Recherche en Infectiologie, Univ Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, F-69007 Lyon, FranceCIRI—Centre International de Recherche en Infectiologie, Univ Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, F-69007 Lyon, FranceCIRI—Centre International de Recherche en Infectiologie, Univ Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, F-69007 Lyon, FranceHepatitis C virus (HCV) infection is a major public health issue leading to chronic liver diseases. HCV particles are unique owing to their particular lipid composition, namely the incorporation of neutral lipids and apolipoproteins. The mechanism of association between HCV virion components and these lipoproteins factors remains poorly understood as well as its impact in subsequent steps of the viral life cycle, such as entry into cells. It was proposed that the lipoprotein biogenesis pathway is involved in HCV morphogenesis; yet, recent evidence indicated that HCV particles can mature and evolve biochemically in the extracellular medium after egress. In addition, several viral, cellular and blood components have been shown to influence and regulate this specific association. Finally, this specific structure and composition of HCV particles was found to influence entry into cells as well as their stability and sensitivity to neutralizing antibodies. Due to its specific particle composition, studying the association of HCV particles with lipoproteins remains an important goal towards the rational design of a protective vaccine.https://www.mdpi.com/1999-4915/12/4/434hepatitis C viruslipidationlipoproteinscell entryimmune escape |
| spellingShingle | François-Loïc Cosset Chloé Mialon Bertrand Boson Christelle Granier Solène Denolly HCV Interplay with Lipoproteins: Inside or Outside the Cells? Viruses hepatitis C virus lipidation lipoproteins cell entry immune escape |
| title | HCV Interplay with Lipoproteins: Inside or Outside the Cells? |
| title_full | HCV Interplay with Lipoproteins: Inside or Outside the Cells? |
| title_fullStr | HCV Interplay with Lipoproteins: Inside or Outside the Cells? |
| title_full_unstemmed | HCV Interplay with Lipoproteins: Inside or Outside the Cells? |
| title_short | HCV Interplay with Lipoproteins: Inside or Outside the Cells? |
| title_sort | hcv interplay with lipoproteins inside or outside the cells |
| topic | hepatitis C virus lipidation lipoproteins cell entry immune escape |
| url | https://www.mdpi.com/1999-4915/12/4/434 |
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