Potential of the Ethyl Acetate Fraction of <i>Padina boergesenii</i> as a Natural UV Filter in Sunscreen Cream Formulation
Brown seaweeds, due to their wide range of bioactive compounds, have a high ability to inhibit free radicals and protect against ultraviolet rays. In the present study, the ethyl acetate fraction (EF) was isolated from the <i>Padina boergesenii</i> brown seaweed. Antioxidant activity (by...
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MDPI AG
2023-01-01
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| author | Soolmaz Soleimani Morteza Yousefzadi Sepideh Babaei Mahani Nezhad Olga N. Pozharitskaya Alexander N. Shikov |
| author_facet | Soolmaz Soleimani Morteza Yousefzadi Sepideh Babaei Mahani Nezhad Olga N. Pozharitskaya Alexander N. Shikov |
| author_sort | Soolmaz Soleimani |
| collection | DOAJ |
| description | Brown seaweeds, due to their wide range of bioactive compounds, have a high ability to inhibit free radicals and protect against ultraviolet rays. In the present study, the ethyl acetate fraction (EF) was isolated from the <i>Padina boergesenii</i> brown seaweed. Antioxidant activity (by the DPPH scavenging activity method) and cytotoxicity against UVB-induced cytotoxicity in HaCaT human keratinocytes were evaluated. Then, this fraction was used as a bio-filter in the formulation of sunscreen, and the physical properties and stability were investigated. The results showed that the EF could inhibit DPPH radical scavenging (54 ± 1%) and cell viability of HaCaT keratinocytes exposed to UVB irradiation (81.2 ± 0.1%). The results of the stability study of the cream formulated with EF showed that at temperatures 4 °C and 25 °C it has high stability; and at 40 °C on the 28th day, a slight decrease in its stability was observed. The pH and Sun Protection Factor of the cream formulated with EF were reported at 5.8 and 20.55, respectively. Also, the DPPH scavenging activity of the cream was not altered for 28 days of storage at temperatures of 4–40 °C. According to our results, it was proved that the sunscreen formulated with EF of <i>P. boergesenii</i> brown seaweed has promising properties and characteristics that can create a new opportunity for the development of cosmetics and skin care products. |
| first_indexed | 2024-03-09T11:55:58Z |
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| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T11:55:58Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
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| series | Life |
| spelling | doaj.art-cca7e34399c54fec962df2f30747f94f2023-11-30T23:09:55ZengMDPI AGLife2075-17292023-01-0113123910.3390/life13010239Potential of the Ethyl Acetate Fraction of <i>Padina boergesenii</i> as a Natural UV Filter in Sunscreen Cream FormulationSoolmaz Soleimani0Morteza Yousefzadi1Sepideh Babaei Mahani Nezhad2Olga N. Pozharitskaya3Alexander N. Shikov4Department of Marine Biology, Faculty of Marine Science and Technology, University of Hormozgan, Bandar Abbas 7916193145, IranDepartment of Biology, Faculty of Science, University of Qom, Qom 3716146611, IranDepartment of Marine Biology, Faculty of Marine Science and Technology, University of Hormozgan, Bandar Abbas 7916193145, IranMurmansk Marine Biological Institute of the Russian Academy of Sciences (MMBI RAS), Vladimirskaya, 17, 183010 Murmansk, RussiaDepartment of Technology of Pharmaceutical Formulations, St. Petersburg State Chemical Pharmaceutical University, Prof. Popov, 14, 197376 Saint-Petersburg, RussiaBrown seaweeds, due to their wide range of bioactive compounds, have a high ability to inhibit free radicals and protect against ultraviolet rays. In the present study, the ethyl acetate fraction (EF) was isolated from the <i>Padina boergesenii</i> brown seaweed. Antioxidant activity (by the DPPH scavenging activity method) and cytotoxicity against UVB-induced cytotoxicity in HaCaT human keratinocytes were evaluated. Then, this fraction was used as a bio-filter in the formulation of sunscreen, and the physical properties and stability were investigated. The results showed that the EF could inhibit DPPH radical scavenging (54 ± 1%) and cell viability of HaCaT keratinocytes exposed to UVB irradiation (81.2 ± 0.1%). The results of the stability study of the cream formulated with EF showed that at temperatures 4 °C and 25 °C it has high stability; and at 40 °C on the 28th day, a slight decrease in its stability was observed. The pH and Sun Protection Factor of the cream formulated with EF were reported at 5.8 and 20.55, respectively. Also, the DPPH scavenging activity of the cream was not altered for 28 days of storage at temperatures of 4–40 °C. According to our results, it was proved that the sunscreen formulated with EF of <i>P. boergesenii</i> brown seaweed has promising properties and characteristics that can create a new opportunity for the development of cosmetics and skin care products.https://www.mdpi.com/2075-1729/13/1/239brown seaweedmarine natural productspolyphenol compoundssunscreen creamcosmetics |
| spellingShingle | Soolmaz Soleimani Morteza Yousefzadi Sepideh Babaei Mahani Nezhad Olga N. Pozharitskaya Alexander N. Shikov Potential of the Ethyl Acetate Fraction of <i>Padina boergesenii</i> as a Natural UV Filter in Sunscreen Cream Formulation Life brown seaweed marine natural products polyphenol compounds sunscreen cream cosmetics |
| title | Potential of the Ethyl Acetate Fraction of <i>Padina boergesenii</i> as a Natural UV Filter in Sunscreen Cream Formulation |
| title_full | Potential of the Ethyl Acetate Fraction of <i>Padina boergesenii</i> as a Natural UV Filter in Sunscreen Cream Formulation |
| title_fullStr | Potential of the Ethyl Acetate Fraction of <i>Padina boergesenii</i> as a Natural UV Filter in Sunscreen Cream Formulation |
| title_full_unstemmed | Potential of the Ethyl Acetate Fraction of <i>Padina boergesenii</i> as a Natural UV Filter in Sunscreen Cream Formulation |
| title_short | Potential of the Ethyl Acetate Fraction of <i>Padina boergesenii</i> as a Natural UV Filter in Sunscreen Cream Formulation |
| title_sort | potential of the ethyl acetate fraction of i padina boergesenii i as a natural uv filter in sunscreen cream formulation |
| topic | brown seaweed marine natural products polyphenol compounds sunscreen cream cosmetics |
| url | https://www.mdpi.com/2075-1729/13/1/239 |
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