Metformin Promotes the Protection of Mice Infected With Plasmodium yoelii Independently of γδ T Cell Expansion

Metformin Promotes the Protection of Mice Infected With Plasmodium yoelii Independently of γδ T Cell Expansion

Adaptive immune responses are critical for protection against infection with Plasmodium parasites. The metabolic state dramatically changes in T cells during activation and the memory phase. Recent findings suggest that metformin, a medication for treating type-II diabetes, enhances T-cell immune re...

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Bibliographic Details
Main Authors: Mana Miyakoda, Ganchimeg Bayarsaikhan, Daisuke Kimura, Masoud Akbari, Heiichiro Udono, Katsuyuki Yui
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
malaria
γδ T cell
clonal expansion
protection
metformin
metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02942/full

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