Inorganic Nanomaterials in Tissue Engineering
In recent decades, the demand for replacement of damaged or broken tissues has increased; this poses the attention on problems related to low donor availability. For this reason, researchers focused their attention on the field of tissue engineering, which allows the development of scaffolds able to...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/6/1127 |
| _version_ | 1797483358028038144 |
|---|---|
| author | Eleonora Bianchi Barbara Vigani César Viseras Franca Ferrari Silvia Rossi Giuseppina Sandri |
| author_facet | Eleonora Bianchi Barbara Vigani César Viseras Franca Ferrari Silvia Rossi Giuseppina Sandri |
| author_sort | Eleonora Bianchi |
| collection | DOAJ |
| description | In recent decades, the demand for replacement of damaged or broken tissues has increased; this poses the attention on problems related to low donor availability. For this reason, researchers focused their attention on the field of tissue engineering, which allows the development of scaffolds able to mimic the tissues’ extracellular matrix. However, tissue replacement and regeneration are complex since scaffolds need to guarantee an adequate hierarchical structured morphology as well as adequate mechanical, chemical, and physical properties to stand the stresses and enhance the new tissue formation. For this purpose, the use of inorganic materials as fillers for the scaffolds has gained great interest in tissue engineering applications, due to their wide range of physicochemical properties as well as their capability to induce biological responses. However, some issues still need to be faced to improve their efficacy. This review focuses on the description of the most effective inorganic nanomaterials (clays, nano-based nanomaterials, metal oxides, metallic nanoparticles) used in tissue engineering and their properties. Particular attention has been devoted to their combination with scaffolds in a wide range of applications. In particular, skin, orthopaedic, and neural tissue engineering have been considered. |
| first_indexed | 2024-03-09T22:46:51Z |
| format | Article |
| id | doaj.art-cca9df824f7e44f79f6ba00c212af879 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T22:46:51Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-cca9df824f7e44f79f6ba00c212af8792023-11-23T18:28:38ZengMDPI AGPharmaceutics1999-49232022-05-01146112710.3390/pharmaceutics14061127Inorganic Nanomaterials in Tissue EngineeringEleonora Bianchi0Barbara Vigani1César Viseras2Franca Ferrari3Silvia Rossi4Giuseppina Sandri5Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Pharmacy and Pharmaceutical Technology, University of Granada, Campus Universitario de Cartuja, 18071 Granada, SpainDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, ItalyIn recent decades, the demand for replacement of damaged or broken tissues has increased; this poses the attention on problems related to low donor availability. For this reason, researchers focused their attention on the field of tissue engineering, which allows the development of scaffolds able to mimic the tissues’ extracellular matrix. However, tissue replacement and regeneration are complex since scaffolds need to guarantee an adequate hierarchical structured morphology as well as adequate mechanical, chemical, and physical properties to stand the stresses and enhance the new tissue formation. For this purpose, the use of inorganic materials as fillers for the scaffolds has gained great interest in tissue engineering applications, due to their wide range of physicochemical properties as well as their capability to induce biological responses. However, some issues still need to be faced to improve their efficacy. This review focuses on the description of the most effective inorganic nanomaterials (clays, nano-based nanomaterials, metal oxides, metallic nanoparticles) used in tissue engineering and their properties. Particular attention has been devoted to their combination with scaffolds in a wide range of applications. In particular, skin, orthopaedic, and neural tissue engineering have been considered.https://www.mdpi.com/1999-4923/14/6/1127nanomaterialsclaysbioceramicsmagnetic nanoparticlesmetal oxidesmetallic nanoparticles |
| spellingShingle | Eleonora Bianchi Barbara Vigani César Viseras Franca Ferrari Silvia Rossi Giuseppina Sandri Inorganic Nanomaterials in Tissue Engineering Pharmaceutics nanomaterials clays bioceramics magnetic nanoparticles metal oxides metallic nanoparticles |
| title | Inorganic Nanomaterials in Tissue Engineering |
| title_full | Inorganic Nanomaterials in Tissue Engineering |
| title_fullStr | Inorganic Nanomaterials in Tissue Engineering |
| title_full_unstemmed | Inorganic Nanomaterials in Tissue Engineering |
| title_short | Inorganic Nanomaterials in Tissue Engineering |
| title_sort | inorganic nanomaterials in tissue engineering |
| topic | nanomaterials clays bioceramics magnetic nanoparticles metal oxides metallic nanoparticles |
| url | https://www.mdpi.com/1999-4923/14/6/1127 |
| work_keys_str_mv | AT eleonorabianchi inorganicnanomaterialsintissueengineering AT barbaravigani inorganicnanomaterialsintissueengineering AT cesarviseras inorganicnanomaterialsintissueengineering AT francaferrari inorganicnanomaterialsintissueengineering AT silviarossi inorganicnanomaterialsintissueengineering AT giuseppinasandri inorganicnanomaterialsintissueengineering |