Bile acids in immunity: Bidirectional mediators between the host and the microbiota
Host-microbiota interactions are bidirectional. On one hand, ecological pressures exerted by the host shape the composition and function of the microbiota. On the other, resident microbes trigger multiple pathways that influence the immunity of the host. Bile acids participate in both parts of this...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.949033/full |
| _version_ | 1818486312193228800 |
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| author | Urszula Godlewska Edyta Bulanda Tomasz P. Wypych |
| author_facet | Urszula Godlewska Edyta Bulanda Tomasz P. Wypych |
| author_sort | Urszula Godlewska |
| collection | DOAJ |
| description | Host-microbiota interactions are bidirectional. On one hand, ecological pressures exerted by the host shape the composition and function of the microbiota. On the other, resident microbes trigger multiple pathways that influence the immunity of the host. Bile acids participate in both parts of this interplay. As host-derived compounds, they display bacteriostatic properties and affect the survival and growth of the members of the microbial community. As microbiota-modified metabolites, they further influence the microbiota composition and, in parallel, modulate the immunity of the host. Here, we provide a comprehensive overview of the mechanisms behind this unique dialogue and discuss how we can harness bile acids to treat intestinal inflammation. |
| first_indexed | 2024-12-10T16:21:15Z |
| format | Article |
| id | doaj.art-ccaa489e5c54495db1490319cdc045e7 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T16:21:15Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ccaa489e5c54495db1490319cdc045e72022-12-22T01:41:49ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.949033949033Bile acids in immunity: Bidirectional mediators between the host and the microbiotaUrszula GodlewskaEdyta BulandaTomasz P. WypychHost-microbiota interactions are bidirectional. On one hand, ecological pressures exerted by the host shape the composition and function of the microbiota. On the other, resident microbes trigger multiple pathways that influence the immunity of the host. Bile acids participate in both parts of this interplay. As host-derived compounds, they display bacteriostatic properties and affect the survival and growth of the members of the microbial community. As microbiota-modified metabolites, they further influence the microbiota composition and, in parallel, modulate the immunity of the host. Here, we provide a comprehensive overview of the mechanisms behind this unique dialogue and discuss how we can harness bile acids to treat intestinal inflammation.https://www.frontiersin.org/articles/10.3389/fimmu.2022.949033/fullbile acidsmicrobial metabolitesimmunityintestinal inflammationhost-microbiota interactions |
| spellingShingle | Urszula Godlewska Edyta Bulanda Tomasz P. Wypych Bile acids in immunity: Bidirectional mediators between the host and the microbiota Frontiers in Immunology bile acids microbial metabolites immunity intestinal inflammation host-microbiota interactions |
| title | Bile acids in immunity: Bidirectional mediators between the host and the microbiota |
| title_full | Bile acids in immunity: Bidirectional mediators between the host and the microbiota |
| title_fullStr | Bile acids in immunity: Bidirectional mediators between the host and the microbiota |
| title_full_unstemmed | Bile acids in immunity: Bidirectional mediators between the host and the microbiota |
| title_short | Bile acids in immunity: Bidirectional mediators between the host and the microbiota |
| title_sort | bile acids in immunity bidirectional mediators between the host and the microbiota |
| topic | bile acids microbial metabolites immunity intestinal inflammation host-microbiota interactions |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.949033/full |
| work_keys_str_mv | AT urszulagodlewska bileacidsinimmunitybidirectionalmediatorsbetweenthehostandthemicrobiota AT edytabulanda bileacidsinimmunitybidirectionalmediatorsbetweenthehostandthemicrobiota AT tomaszpwypych bileacidsinimmunitybidirectionalmediatorsbetweenthehostandthemicrobiota |