TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions.

AngII and TGF-β interact in development of thoracic and abdominal aortic diseases, although there are many facets of this interaction that have not been clearly defined. The aim of the present study was to determine the effects of TGF-β neutralization on AngII induced-aortic pathologies. Male C57BL/...

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Bibliografiske detaljer
Main Authors: Xiaofeng Chen, Debra L Rateri, Deborah A Howatt, Anju Balakrishnan, Jessica J Moorleghen, Lisa A Cassis, Alan Daugherty
Format: Article
Sprog:English
Udgivet: Public Library of Science (PLoS) 2016-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC4841552?pdf=render