Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp2)−H bonds
Directed activation of C–H bonds usually occurs through 5-membered metallacycles, which poses limitations of regiochemistry. Herein, the authors use a phosphine oxide-ligated Ni−Al bimetallic catalyst to enable β-C−H bond-involved hydroarylations of alkynes via a rare 7-membered nickelacycle.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30367-8 |
| _version_ | 1828794393571622912 |
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| author | Shao-Long Qi Yu-Peng Liu Yi Li Yu-Xin Luan Mengchun Ye |
| author_facet | Shao-Long Qi Yu-Peng Liu Yi Li Yu-Xin Luan Mengchun Ye |
| author_sort | Shao-Long Qi |
| collection | DOAJ |
| description | Directed activation of C–H bonds usually occurs through 5-membered metallacycles, which poses limitations of regiochemistry. Herein, the authors use a phosphine oxide-ligated Ni−Al bimetallic catalyst to enable β-C−H bond-involved hydroarylations of alkynes via a rare 7-membered nickelacycle. |
| first_indexed | 2024-12-12T03:44:31Z |
| format | Article |
| id | doaj.art-ccaaa99a0bee4eba989a8d334b7343b6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T03:44:31Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ccaaa99a0bee4eba989a8d334b7343b62022-12-22T00:39:36ZengNature PortfolioNature Communications2041-17232022-05-011311910.1038/s41467-022-30367-8Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp2)−H bondsShao-Long Qi0Yu-Peng Liu1Yi Li2Yu-Xin Luan3Mengchun Ye4State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityState Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai UniversityDirected activation of C–H bonds usually occurs through 5-membered metallacycles, which poses limitations of regiochemistry. Herein, the authors use a phosphine oxide-ligated Ni−Al bimetallic catalyst to enable β-C−H bond-involved hydroarylations of alkynes via a rare 7-membered nickelacycle.https://doi.org/10.1038/s41467-022-30367-8 |
| spellingShingle | Shao-Long Qi Yu-Peng Liu Yi Li Yu-Xin Luan Mengchun Ye Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp2)−H bonds Nature Communications |
| title | Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp2)−H bonds |
| title_full | Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp2)−H bonds |
| title_fullStr | Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp2)−H bonds |
| title_full_unstemmed | Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp2)−H bonds |
| title_short | Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp2)−H bonds |
| title_sort | ni catalyzed hydroarylation of alkynes with unactivated β c sp2 h bonds |
| url | https://doi.org/10.1038/s41467-022-30367-8 |
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