Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states

Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states

Abstract Background Genomic imprinting, resulting in parent-of-origin specific gene expression, plays a critical role in mammalian development. Here, we apply allele-specific RNA-seq on isogenic B6D2F1 mice to assay imprinted genes in tissues from early embryonic tissues between E3.5 and E7.25 and i...

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Bibliographic Details
Main Authors: René A. M. Dirks, Guido van Mierlo, Hindrik H. D. Kerstens, Andreia S. Bernardo, Julianna Kobolák, István Bock, Julien Maruotti, Roger A. Pedersen, András Dinnyés, Martijn A. Huynen, Alice Jouneau, Hendrik Marks
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Epigenetics & Chromatin
Subjects:
Genomic imprinting
Allele-specific RNA-seq
Mouse embryo
Embryonic stem cells
ESCs
EpiSCs
Online Access:http://link.springer.com/article/10.1186/s13072-019-0259-8

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