Lichenoid drug eruption induced by chlordiazepoxide
Lichenoid drug reaction is a cutaneous drug eruption due to a Type IV delayed hypersensitivity reaction. It usually occurs months to years following the intake of the drug and is characterized by purple, flat, polygonal papules that spread symmetrically and diffusely across the body. We report the c...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Dermatology and Dermatologic Surgery |
| Subjects: | |
| Online Access: | http://www.jddsjournal.org/article.asp?issn=2352-2410;year=2022;volume=26;issue=3;spage=29;epage=31;aulast=Alkhuzaim |
| _version_ | 1811277034792419328 |
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| author | Osamah M Alkhuzaim |
| author_facet | Osamah M Alkhuzaim |
| author_sort | Osamah M Alkhuzaim |
| collection | DOAJ |
| description | Lichenoid drug reaction is a cutaneous drug eruption due to a Type IV delayed hypersensitivity reaction. It usually occurs months to years following the intake of the drug and is characterized by purple, flat, polygonal papules that spread symmetrically and diffusely across the body. We report the case of a 26-year-old female, who was on chlordiazepoxide for the treatment of insomnia, and presented with multiple, annular, purple, scaly, itchy plaques over her breasts. The eruption progressed to involve the thighs and buccal mucosa and did not respond to topical antifungals. Skin biopsy revealed lichenoid lymphocytic infiltrate consistent with lichen planus. After discontinuation of chlordiazepoxide, her skin eruption significantly improved within 3 months. To our knowledge, this is the first case report of a patient who developed a lichenoid drug reaction to chlordiazepoxide. |
| first_indexed | 2024-04-13T00:08:29Z |
| format | Article |
| id | doaj.art-ccabc3c530ba46e8afd5aefad1c6e88d |
| institution | Directory Open Access Journal |
| issn | 2352-2410 2352-2429 |
| language | English |
| last_indexed | 2024-04-13T00:08:29Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Dermatology and Dermatologic Surgery |
| spelling | doaj.art-ccabc3c530ba46e8afd5aefad1c6e88d2022-12-22T03:11:10ZengWolters Kluwer Medknow PublicationsJournal of Dermatology and Dermatologic Surgery2352-24102352-24292022-01-01263293110.4103/jdds.jdds_35_20Lichenoid drug eruption induced by chlordiazepoxideOsamah M AlkhuzaimLichenoid drug reaction is a cutaneous drug eruption due to a Type IV delayed hypersensitivity reaction. It usually occurs months to years following the intake of the drug and is characterized by purple, flat, polygonal papules that spread symmetrically and diffusely across the body. We report the case of a 26-year-old female, who was on chlordiazepoxide for the treatment of insomnia, and presented with multiple, annular, purple, scaly, itchy plaques over her breasts. The eruption progressed to involve the thighs and buccal mucosa and did not respond to topical antifungals. Skin biopsy revealed lichenoid lymphocytic infiltrate consistent with lichen planus. After discontinuation of chlordiazepoxide, her skin eruption significantly improved within 3 months. To our knowledge, this is the first case report of a patient who developed a lichenoid drug reaction to chlordiazepoxide.http://www.jddsjournal.org/article.asp?issn=2352-2410;year=2022;volume=26;issue=3;spage=29;epage=31;aulast=Alkhuzaimbenzodiazepinechlordiazepoxidelichenoid drug |
| spellingShingle | Osamah M Alkhuzaim Lichenoid drug eruption induced by chlordiazepoxide Journal of Dermatology and Dermatologic Surgery benzodiazepine chlordiazepoxide lichenoid drug |
| title | Lichenoid drug eruption induced by chlordiazepoxide |
| title_full | Lichenoid drug eruption induced by chlordiazepoxide |
| title_fullStr | Lichenoid drug eruption induced by chlordiazepoxide |
| title_full_unstemmed | Lichenoid drug eruption induced by chlordiazepoxide |
| title_short | Lichenoid drug eruption induced by chlordiazepoxide |
| title_sort | lichenoid drug eruption induced by chlordiazepoxide |
| topic | benzodiazepine chlordiazepoxide lichenoid drug |
| url | http://www.jddsjournal.org/article.asp?issn=2352-2410;year=2022;volume=26;issue=3;spage=29;epage=31;aulast=Alkhuzaim |
| work_keys_str_mv | AT osamahmalkhuzaim lichenoiddrugeruptioninducedbychlordiazepoxide |