Local and Global Protein Interactions Contribute to Residue Entrenchment in Beta-Lactamase TEM-1

Local and Global Protein Interactions Contribute to Residue Entrenchment in Beta-Lactamase TEM-1

Due to their rapid evolution and their impact on healthcare, beta-lactamases, protein degrading beta-lactam antibiotics, are used as generic models of protein evolution. Therefore, we investigated the mutation effects in two distant beta-lactamases, TEM-1 and CTX-M-15. Interestingly, we found a site...

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Bibliographic Details
Main Authors: André Birgy, Mélanie Magnan, Claire Amaris Hobson, Matteo Figliuzzi, Karine Panigoni, Cyrielle Codde, Olivier Tenaillon, Hervé Jacquier
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Antibiotics
Subjects:
entrenchment
protein stability
TEM-1 beta-lactamase
CTX-M-15 beta-lactamase
M182T mutation
Online Access:https://www.mdpi.com/2079-6382/11/5/652

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