DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus
Group 2 innate lymphoid cells (ILC2s) are immune cells present in adipose tissue that contribute to metabolic homeostasis. Here the authors show that Death Receptor 3 (DR3) engagement on ILC2s ameliorates glucose tolerance, protects against insulin-resistance onset and reverses established insulin-r...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18601-7 |
| _version_ | 1818846010765475840 |
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| author | Pedram Shafiei-Jahani Benjamin P. Hurrell Lauriane Galle-Treger Doumet Georges Helou Emily Howard Jacob Painter Richard Lo Gavin Lewis Pejman Soroosh Omid Akbari |
| author_facet | Pedram Shafiei-Jahani Benjamin P. Hurrell Lauriane Galle-Treger Doumet Georges Helou Emily Howard Jacob Painter Richard Lo Gavin Lewis Pejman Soroosh Omid Akbari |
| author_sort | Pedram Shafiei-Jahani |
| collection | DOAJ |
| description | Group 2 innate lymphoid cells (ILC2s) are immune cells present in adipose tissue that contribute to metabolic homeostasis. Here the authors show that Death Receptor 3 (DR3) engagement on ILC2s ameliorates glucose tolerance, protects against insulin-resistance onset and reverses established insulin-resistance. |
| first_indexed | 2024-12-19T05:38:45Z |
| format | Article |
| id | doaj.art-ccb0b1c8242f4157b1256882b0fb6cb3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T05:38:45Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ccb0b1c8242f4157b1256882b0fb6cb32022-12-21T20:34:04ZengNature PortfolioNature Communications2041-17232020-09-0111111510.1038/s41467-020-18601-7DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitusPedram Shafiei-Jahani0Benjamin P. Hurrell1Lauriane Galle-Treger2Doumet Georges Helou3Emily Howard4Jacob Painter5Richard Lo6Gavin Lewis7Pejman Soroosh8Omid Akbari9Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern CaliforniaDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern CaliforniaDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern CaliforniaDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern CaliforniaDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern CaliforniaDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern CaliforniaDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern CaliforniaJanssen Research and DevelopmentJanssen Research and DevelopmentDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern CaliforniaGroup 2 innate lymphoid cells (ILC2s) are immune cells present in adipose tissue that contribute to metabolic homeostasis. Here the authors show that Death Receptor 3 (DR3) engagement on ILC2s ameliorates glucose tolerance, protects against insulin-resistance onset and reverses established insulin-resistance.https://doi.org/10.1038/s41467-020-18601-7 |
| spellingShingle | Pedram Shafiei-Jahani Benjamin P. Hurrell Lauriane Galle-Treger Doumet Georges Helou Emily Howard Jacob Painter Richard Lo Gavin Lewis Pejman Soroosh Omid Akbari DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus Nature Communications |
| title | DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus |
| title_full | DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus |
| title_fullStr | DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus |
| title_full_unstemmed | DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus |
| title_short | DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus |
| title_sort | dr3 stimulation of adipose resident ilc2s ameliorates type 2 diabetes mellitus |
| url | https://doi.org/10.1038/s41467-020-18601-7 |
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