Prevalence and determinants of antimicrobial resistance of gram-negative bacteria in intensive care unit
Antimicrobial resistance (AMR) has become a concerning health issue worldwide, and this resistance leads to poor treatment outcomes and high mortality, especially, AMR of NP in ICU. To determine the reality of AMR and find the factors related to AMR of NP in the ICU. We performed a cross-sectional s...
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| Format: | Article |
| Language: | English |
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Faculty of Pharmacy, Mahidol University
2022-11-01
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| Series: | Pharmaceutical Sciences Asia |
| Subjects: | |
| Online Access: | https://pharmacy.mahidol.ac.th/journal/_files/2022-49-6_6.pdf |
| _version_ | 1828305959471022080 |
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| author | Van Duong Thi Thanh Thang Nguyen Truyen Ngo Van Thu Vo Pham Minh |
| author_facet | Van Duong Thi Thanh Thang Nguyen Truyen Ngo Van Thu Vo Pham Minh |
| author_sort | Van Duong Thi Thanh |
| collection | DOAJ |
| description | Antimicrobial resistance (AMR) has become a concerning health issue worldwide, and this resistance leads to poor treatment outcomes and high mortality, especially, AMR of NP in ICU. To determine the reality of AMR and find the factors related to AMR of NP in the ICU. We performed a cross-sectional study in the ICU Department from July 2015 to July 2019. We calculated the incidence of the degree of multidrug-resistant strains and the percentages of factors related to AMR. Data management and analysis were performed by SPSS version 22.0. Of the initial observation of 281 patients, all participants had NP due to gram-negative bacteria; 91 (32.4%) were early-onset and 190 (67.6%) were lately-onset NP. Out of all pathogens examined, above 80% were resistant to quinolone, carbapenem, and cephalosporin. Moreover, multiple drug resistance in bacteria was about 87.5%. Furthermore, bacteria, changed anti-biotics have been significantly associated with the multi-resistance of bacteria. Besides, the increase in antibiotic use, especially ciprofloxacin and imipenem, is also related to antibiotic resistance. These results show that the resistance to quinolones, carbapenem, and cephalosporin is high in the ICU, with rates exceeding 80%. Furthermore, the bacteria, change of antibiotics, and the increasing use of antibiotics have been significantly associated with multiple antibiotic resistance. |
| first_indexed | 2024-04-13T14:37:25Z |
| format | Article |
| id | doaj.art-ccb0ddb12f894a9294488a34a6370018 |
| institution | Directory Open Access Journal |
| issn | 2586-8470 |
| language | English |
| last_indexed | 2024-04-13T14:37:25Z |
| publishDate | 2022-11-01 |
| publisher | Faculty of Pharmacy, Mahidol University |
| record_format | Article |
| series | Pharmaceutical Sciences Asia |
| spelling | doaj.art-ccb0ddb12f894a9294488a34a63700182022-12-22T02:43:00ZengFaculty of Pharmacy, Mahidol UniversityPharmaceutical Sciences Asia2586-84702022-11-0149656857510.29090/psa.2022.06.22.104Prevalence and determinants of antimicrobial resistance of gram-negative bacteria in intensive care unitVan Duong Thi Thanh0Thang Nguyen1Truyen Ngo Van2Thu Vo Pham Minh3Faculty of Medicine, Can tho University of medicine and pharmacy, VietnamFaculty of Pharmacy, Can tho University of medicine and pharmacy, VietnamFaculty of Medicine, Can tho University of medicine and pharmacy, VietnamFaculty of Medicine, Can tho University of medicine and pharmacy, VietnamAntimicrobial resistance (AMR) has become a concerning health issue worldwide, and this resistance leads to poor treatment outcomes and high mortality, especially, AMR of NP in ICU. To determine the reality of AMR and find the factors related to AMR of NP in the ICU. We performed a cross-sectional study in the ICU Department from July 2015 to July 2019. We calculated the incidence of the degree of multidrug-resistant strains and the percentages of factors related to AMR. Data management and analysis were performed by SPSS version 22.0. Of the initial observation of 281 patients, all participants had NP due to gram-negative bacteria; 91 (32.4%) were early-onset and 190 (67.6%) were lately-onset NP. Out of all pathogens examined, above 80% were resistant to quinolone, carbapenem, and cephalosporin. Moreover, multiple drug resistance in bacteria was about 87.5%. Furthermore, bacteria, changed anti-biotics have been significantly associated with the multi-resistance of bacteria. Besides, the increase in antibiotic use, especially ciprofloxacin and imipenem, is also related to antibiotic resistance. These results show that the resistance to quinolones, carbapenem, and cephalosporin is high in the ICU, with rates exceeding 80%. Furthermore, the bacteria, change of antibiotics, and the increasing use of antibiotics have been significantly associated with multiple antibiotic resistance.https://pharmacy.mahidol.ac.th/journal/_files/2022-49-6_6.pdfantimicrobial resistancegram-negative bacteriaintensive care unit |
| spellingShingle | Van Duong Thi Thanh Thang Nguyen Truyen Ngo Van Thu Vo Pham Minh Prevalence and determinants of antimicrobial resistance of gram-negative bacteria in intensive care unit Pharmaceutical Sciences Asia antimicrobial resistance gram-negative bacteria intensive care unit |
| title | Prevalence and determinants of antimicrobial resistance of gram-negative bacteria in intensive care unit |
| title_full | Prevalence and determinants of antimicrobial resistance of gram-negative bacteria in intensive care unit |
| title_fullStr | Prevalence and determinants of antimicrobial resistance of gram-negative bacteria in intensive care unit |
| title_full_unstemmed | Prevalence and determinants of antimicrobial resistance of gram-negative bacteria in intensive care unit |
| title_short | Prevalence and determinants of antimicrobial resistance of gram-negative bacteria in intensive care unit |
| title_sort | prevalence and determinants of antimicrobial resistance of gram negative bacteria in intensive care unit |
| topic | antimicrobial resistance gram-negative bacteria intensive care unit |
| url | https://pharmacy.mahidol.ac.th/journal/_files/2022-49-6_6.pdf |
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