Thiopeptide Antibiotics: Retrospective and Recent Advances
Thiopeptides, or thiazolyl peptides, are a relatively new family of antibiotics that already counts with more than one hundred different entities. Although they are mainly isolated from soil bacteria, during the last decade, new members have been isolated from marine samples. Far from being limited...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-01-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/12/1/317 |
| _version_ | 1798005709224280064 |
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| author | Xavier Just-Baringo Fernando Albericio Mercedes Álvarez |
| author_facet | Xavier Just-Baringo Fernando Albericio Mercedes Álvarez |
| author_sort | Xavier Just-Baringo |
| collection | DOAJ |
| description | Thiopeptides, or thiazolyl peptides, are a relatively new family of antibiotics that already counts with more than one hundred different entities. Although they are mainly isolated from soil bacteria, during the last decade, new members have been isolated from marine samples. Far from being limited to their innate antibacterial activity, thiopeptides have been found to possess a wide range of biological properties, including anticancer, antiplasmodial, immunosuppressive, etc. In spite of their ribosomal origin, these highly posttranslationally processed peptides have posed a fascinating synthetic challenge, prompting the development of various methodologies and strategies. Regardless of their limited solubility, intensive investigations are bringing thiopeptide derivatives closer to the clinic, where they are likely to show their veritable therapeutic potential. |
| first_indexed | 2024-04-11T12:44:44Z |
| format | Article |
| id | doaj.art-ccb1ef7992784c47b667a60d0cce2709 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T12:44:44Z |
| publishDate | 2014-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-ccb1ef7992784c47b667a60d0cce27092022-12-22T04:23:25ZengMDPI AGMarine Drugs1660-33972014-01-0112131735110.3390/md12010317md12010317Thiopeptide Antibiotics: Retrospective and Recent AdvancesXavier Just-Baringo0Fernando Albericio1Mercedes Álvarez2Institute for Research in Biomedicine, Barcelona Science Park-University of Barcelona, Baldiri Reixac 10, Barcelona 08028, SpainInstitute for Research in Biomedicine, Barcelona Science Park-University of Barcelona, Baldiri Reixac 10, Barcelona 08028, SpainInstitute for Research in Biomedicine, Barcelona Science Park-University of Barcelona, Baldiri Reixac 10, Barcelona 08028, SpainThiopeptides, or thiazolyl peptides, are a relatively new family of antibiotics that already counts with more than one hundred different entities. Although they are mainly isolated from soil bacteria, during the last decade, new members have been isolated from marine samples. Far from being limited to their innate antibacterial activity, thiopeptides have been found to possess a wide range of biological properties, including anticancer, antiplasmodial, immunosuppressive, etc. In spite of their ribosomal origin, these highly posttranslationally processed peptides have posed a fascinating synthetic challenge, prompting the development of various methodologies and strategies. Regardless of their limited solubility, intensive investigations are bringing thiopeptide derivatives closer to the clinic, where they are likely to show their veritable therapeutic potential.http://www.mdpi.com/1660-3397/12/1/317thiopeptidesantibioticsnatural productspeptidesheterocyclesthiazoleoxazoledehydroamino acidspyridine |
| spellingShingle | Xavier Just-Baringo Fernando Albericio Mercedes Álvarez Thiopeptide Antibiotics: Retrospective and Recent Advances Marine Drugs thiopeptides antibiotics natural products peptides heterocycles thiazole oxazole dehydroamino acids pyridine |
| title | Thiopeptide Antibiotics: Retrospective and Recent Advances |
| title_full | Thiopeptide Antibiotics: Retrospective and Recent Advances |
| title_fullStr | Thiopeptide Antibiotics: Retrospective and Recent Advances |
| title_full_unstemmed | Thiopeptide Antibiotics: Retrospective and Recent Advances |
| title_short | Thiopeptide Antibiotics: Retrospective and Recent Advances |
| title_sort | thiopeptide antibiotics retrospective and recent advances |
| topic | thiopeptides antibiotics natural products peptides heterocycles thiazole oxazole dehydroamino acids pyridine |
| url | http://www.mdpi.com/1660-3397/12/1/317 |
| work_keys_str_mv | AT xavierjustbaringo thiopeptideantibioticsretrospectiveandrecentadvances AT fernandoalbericio thiopeptideantibioticsretrospectiveandrecentadvances AT mercedesalvarez thiopeptideantibioticsretrospectiveandrecentadvances |