Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration
Bone possesses an inherent capacity to fix itself. However, when a defect larger than a critical size appears, external solutions must be applied. Traditionally, an autograft has been the most used solution in these situations. However, it presents some issues such as donor-site morbidity. In this c...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-11-01
|
| Series: | Materials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1996-1944/13/22/5083 |
| _version_ | 1797548214569664512 |
|---|---|
| author | Sara Lopez de Armentia Juan Carlos del Real Eva Paz Nicholas Dunne |
| author_facet | Sara Lopez de Armentia Juan Carlos del Real Eva Paz Nicholas Dunne |
| author_sort | Sara Lopez de Armentia |
| collection | DOAJ |
| description | Bone possesses an inherent capacity to fix itself. However, when a defect larger than a critical size appears, external solutions must be applied. Traditionally, an autograft has been the most used solution in these situations. However, it presents some issues such as donor-site morbidity. In this context, porous biodegradable scaffolds have emerged as an interesting solution. They act as external support for cell growth and degrade when the defect is repaired. For an adequate performance, these scaffolds must meet specific requirements: biocompatibility, interconnected porosity, mechanical properties and biodegradability. To obtain the required porosity, many methods have conventionally been used (e.g., electrospinning, freeze-drying and salt-leaching). However, from the development of additive manufacturing methods a promising solution for this application has been proposed since such methods allow the complete customisation and control of scaffold geometry and porosity. Furthermore, carbon-based nanomaterials present the potential to impart osteoconductivity and antimicrobial properties and reinforce the matrix from a mechanical perspective. These properties make them ideal for use as nanomaterials to improve the properties and performance of scaffolds for bone tissue engineering. This work explores the potential research opportunities and challenges of 3D printed biodegradable composite-based scaffolds containing carbon-based nanomaterials for bone tissue engineering applications. |
| first_indexed | 2024-03-10T14:56:13Z |
| format | Article |
| id | doaj.art-ccb2f0db62af430aafdd46d8501a8810 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T14:56:13Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-ccb2f0db62af430aafdd46d8501a88102023-11-20T20:34:07ZengMDPI AGMaterials1996-19442020-11-011322508310.3390/ma13225083Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone RegenerationSara Lopez de Armentia0Juan Carlos del Real1Eva Paz2Nicholas Dunne3Institute for Research in Technology/Mechanical Engineering Dept., Universidad Pontificia Comillas, Alberto Aguilera 25, 28015 Madrid, SpainInstitute for Research in Technology/Mechanical Engineering Dept., Universidad Pontificia Comillas, Alberto Aguilera 25, 28015 Madrid, SpainInstitute for Research in Technology/Mechanical Engineering Dept., Universidad Pontificia Comillas, Alberto Aguilera 25, 28015 Madrid, SpainCentre for Medical Engineering Research, School of Mechanical and Manufacturing Engineering, Dublin City University, Stokes Building, Collins Avenue, Dublin 9, IrelandBone possesses an inherent capacity to fix itself. However, when a defect larger than a critical size appears, external solutions must be applied. Traditionally, an autograft has been the most used solution in these situations. However, it presents some issues such as donor-site morbidity. In this context, porous biodegradable scaffolds have emerged as an interesting solution. They act as external support for cell growth and degrade when the defect is repaired. For an adequate performance, these scaffolds must meet specific requirements: biocompatibility, interconnected porosity, mechanical properties and biodegradability. To obtain the required porosity, many methods have conventionally been used (e.g., electrospinning, freeze-drying and salt-leaching). However, from the development of additive manufacturing methods a promising solution for this application has been proposed since such methods allow the complete customisation and control of scaffold geometry and porosity. Furthermore, carbon-based nanomaterials present the potential to impart osteoconductivity and antimicrobial properties and reinforce the matrix from a mechanical perspective. These properties make them ideal for use as nanomaterials to improve the properties and performance of scaffolds for bone tissue engineering. This work explores the potential research opportunities and challenges of 3D printed biodegradable composite-based scaffolds containing carbon-based nanomaterials for bone tissue engineering applications.https://www.mdpi.com/1996-1944/13/22/5083biodegradable scaffoldsbone tissue engineeringcarbon-based nanomaterialsadditive manufacturing |
| spellingShingle | Sara Lopez de Armentia Juan Carlos del Real Eva Paz Nicholas Dunne Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration Materials biodegradable scaffolds bone tissue engineering carbon-based nanomaterials additive manufacturing |
| title | Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration |
| title_full | Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration |
| title_fullStr | Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration |
| title_full_unstemmed | Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration |
| title_short | Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration |
| title_sort | advances in biodegradable 3d printed scaffolds with carbon based nanomaterials for bone regeneration |
| topic | biodegradable scaffolds bone tissue engineering carbon-based nanomaterials additive manufacturing |
| url | https://www.mdpi.com/1996-1944/13/22/5083 |
| work_keys_str_mv | AT saralopezdearmentia advancesinbiodegradable3dprintedscaffoldswithcarbonbasednanomaterialsforboneregeneration AT juancarlosdelreal advancesinbiodegradable3dprintedscaffoldswithcarbonbasednanomaterialsforboneregeneration AT evapaz advancesinbiodegradable3dprintedscaffoldswithcarbonbasednanomaterialsforboneregeneration AT nicholasdunne advancesinbiodegradable3dprintedscaffoldswithcarbonbasednanomaterialsforboneregeneration |