The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development.
THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3527488?pdf=render |
| _version_ | 1819101914774634496 |
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| author | Maikel Castellano-Pozo Tatiana García-Muse Andrés Aguilera |
| author_facet | Maikel Castellano-Pozo Tatiana García-Muse Andrés Aguilera |
| author_sort | Maikel Castellano-Pozo |
| collection | DOAJ |
| description | THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological relevance of THO during development and in adult organisms. Using Caenorhabditis elegans as a model system we show that the THO complex is essential for mitotic genome integrity and the developmentally regulated mitotic cell cycles occurring during late postembryonic stages. |
| first_indexed | 2024-12-22T01:26:15Z |
| format | Article |
| id | doaj.art-ccb46ccdd400408b98343beb202759d5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T01:26:15Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ccb46ccdd400408b98343beb202759d52022-12-21T18:43:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5244710.1371/journal.pone.0052447The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development.Maikel Castellano-PozoTatiana García-MuseAndrés AguileraTHO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological relevance of THO during development and in adult organisms. Using Caenorhabditis elegans as a model system we show that the THO complex is essential for mitotic genome integrity and the developmentally regulated mitotic cell cycles occurring during late postembryonic stages.http://europepmc.org/articles/PMC3527488?pdf=render |
| spellingShingle | Maikel Castellano-Pozo Tatiana García-Muse Andrés Aguilera The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development. PLoS ONE |
| title | The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development. |
| title_full | The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development. |
| title_fullStr | The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development. |
| title_full_unstemmed | The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development. |
| title_short | The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development. |
| title_sort | caenorhabditis elegans tho complex is required for the mitotic cell cycle and development |
| url | http://europepmc.org/articles/PMC3527488?pdf=render |
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