The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development.

The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development.

THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological...

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Bibliographic Details
Main Authors: Maikel Castellano-Pozo, Tatiana García-Muse, Andrés Aguilera
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3527488?pdf=render

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