Development of a rapid detection method for the macrolide resistance gene in Mycobacterium avium using the amplification refractory mutation system–loop-mediated isothermal amplification method

Development of a rapid detection method for the macrolide resistance gene in Mycobacterium avium using the amplification refractory mutation system–loop-mediated isothermal amplification method

ABSTRACTMacrolide antibiotics such as clarithromycin (CLR) and azithromycin are the key drugs used in multidrug therapy for Mycobacterium avium complex (MAC) diseases. For these antibacterial drugs, drug susceptibility has been correlated with clinical response in MAC diseases. We have previously de...

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Bibliographic Details
Main Authors: Takayuki Inagaki, Shoki Asahi, Kenji Ogawa, Taku Nakagawa, Teruko Ohkura, Yukari Osada, Toshiaki Nikai, Kiyofumi Yamada, Tetsuya Yagi, Kei-ichi Uchiya
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:Microbiology Spectrum
Subjects:
23S rRNA
amplification refractory mutation system
loop-mediated isothermal amplification
clarithromycin
drug-resistance gene
Mycobacterium avium
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02339-23

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