Sex‐ and Age Group‐Specific Fracture Incidence Rates Trends for Type 1 and 2 Diabetes Mellitus
ABSTRACT The incidence of major osteoporotic fractures has declined in men and women in Western countries over the last two decades. Although fracture risk is higher in persons with diabetes mellitus, trends of fractures remain unknown in men and women with diabetes. We investigated the trends in fr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | JBMR Plus |
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| Online Access: | https://doi.org/10.1002/jbm4.10836 |
| _version_ | 1797626854990938112 |
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| author | Mohamad I Nasser Annika Vestergaard Kvist Peter Vestergaard Richard Eastell Andrea M Burden Morten Frost |
| author_facet | Mohamad I Nasser Annika Vestergaard Kvist Peter Vestergaard Richard Eastell Andrea M Burden Morten Frost |
| author_sort | Mohamad I Nasser |
| collection | DOAJ |
| description | ABSTRACT The incidence of major osteoporotic fractures has declined in men and women in Western countries over the last two decades. Although fracture risk is higher in persons with diabetes mellitus, trends of fractures remain unknown in men and women with diabetes. We investigated the trends in fracture incidence rates (IRs) in men and women with type 1 diabetes mellitus (T1D) and type 2 diabetes mellitus (T2D) in Denmark between 1997 and 2017. We identified men and women aged 18+ years who sustained a fracture (excluding skull and facial fractures) between 1997 and 2017 using the Danish National Patient Registry. We calculated sex‐specific IRs of fractures per 10,000 person‐years separately in persons with T1D, T2D, or without diabetes. Furthermore, we compared median IRs of the first 5 years (1997–2002) to the median IRs of the last 5 years (2012–2017). We identified 1,235,628 persons with fractures including 4863 (43.6% women) with T1D, 65,366 (57.5% women) with T2D, and 1,165,399 (54.1% women) without diabetes. The median IRs of fractures declined 20.2%, 19.9%, and 7.8% in men with T1D, T2D, and without diabetes, respectively (p‐trend <0.05). The median IRs decreased 6.4% in women with T1D (p‐trend = 0.35) and 25.6% in women with T2D (p‐trend <0.05) but increased 2.3% in women without diabetes (p‐trend = 0.08). Fracture IRs decreased in men with both diabetes types and only in women with T2D, highlighting the need for further attention behind the stable trend observed in women with T1D. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research. |
| first_indexed | 2024-03-11T10:16:08Z |
| format | Article |
| id | doaj.art-ccb76900420c4e56bf0edc9a08e287d1 |
| institution | Directory Open Access Journal |
| issn | 2473-4039 |
| language | English |
| last_indexed | 2024-03-11T10:16:08Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | JBMR Plus |
| spelling | doaj.art-ccb76900420c4e56bf0edc9a08e287d12023-11-16T09:31:51ZengWileyJBMR Plus2473-40392023-11-01711n/an/a10.1002/jbm4.10836Sex‐ and Age Group‐Specific Fracture Incidence Rates Trends for Type 1 and 2 Diabetes MellitusMohamad I Nasser0Annika Vestergaard Kvist1Peter Vestergaard2Richard Eastell3Andrea M Burden4Morten Frost5Department of Endocrinology and Metabolism, Molecular Endocrinology Stem Cell Research Unit (KMEB) Odense University Hospital Odense DenmarkDepartment of Endocrinology and Metabolism, Molecular Endocrinology Stem Cell Research Unit (KMEB) Odense University Hospital Odense DenmarkSteno Diabetes Center North Denmark Aalborg University Hospital Aalborg DenmarkAcademic Unit of Bone Metabolism University of Sheffield Sheffield UKPharmacoepidemiology Group, Institute of Pharmaceutical Sciences ETH Zurich Zurich SwitzerlandDepartment of Endocrinology and Metabolism, Molecular Endocrinology Stem Cell Research Unit (KMEB) Odense University Hospital Odense DenmarkABSTRACT The incidence of major osteoporotic fractures has declined in men and women in Western countries over the last two decades. Although fracture risk is higher in persons with diabetes mellitus, trends of fractures remain unknown in men and women with diabetes. We investigated the trends in fracture incidence rates (IRs) in men and women with type 1 diabetes mellitus (T1D) and type 2 diabetes mellitus (T2D) in Denmark between 1997 and 2017. We identified men and women aged 18+ years who sustained a fracture (excluding skull and facial fractures) between 1997 and 2017 using the Danish National Patient Registry. We calculated sex‐specific IRs of fractures per 10,000 person‐years separately in persons with T1D, T2D, or without diabetes. Furthermore, we compared median IRs of the first 5 years (1997–2002) to the median IRs of the last 5 years (2012–2017). We identified 1,235,628 persons with fractures including 4863 (43.6% women) with T1D, 65,366 (57.5% women) with T2D, and 1,165,399 (54.1% women) without diabetes. The median IRs of fractures declined 20.2%, 19.9%, and 7.8% in men with T1D, T2D, and without diabetes, respectively (p‐trend <0.05). The median IRs decreased 6.4% in women with T1D (p‐trend = 0.35) and 25.6% in women with T2D (p‐trend <0.05) but increased 2.3% in women without diabetes (p‐trend = 0.08). Fracture IRs decreased in men with both diabetes types and only in women with T2D, highlighting the need for further attention behind the stable trend observed in women with T1D. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.https://doi.org/10.1002/jbm4.10836FRACTURESINCIDENCETRENDSTYPE 1 DIABETES MELLITUSTYPE 2 DIABETES MELLITUS |
| spellingShingle | Mohamad I Nasser Annika Vestergaard Kvist Peter Vestergaard Richard Eastell Andrea M Burden Morten Frost Sex‐ and Age Group‐Specific Fracture Incidence Rates Trends for Type 1 and 2 Diabetes Mellitus JBMR Plus FRACTURES INCIDENCE TRENDS TYPE 1 DIABETES MELLITUS TYPE 2 DIABETES MELLITUS |
| title | Sex‐ and Age Group‐Specific Fracture Incidence Rates Trends for Type 1 and 2 Diabetes Mellitus |
| title_full | Sex‐ and Age Group‐Specific Fracture Incidence Rates Trends for Type 1 and 2 Diabetes Mellitus |
| title_fullStr | Sex‐ and Age Group‐Specific Fracture Incidence Rates Trends for Type 1 and 2 Diabetes Mellitus |
| title_full_unstemmed | Sex‐ and Age Group‐Specific Fracture Incidence Rates Trends for Type 1 and 2 Diabetes Mellitus |
| title_short | Sex‐ and Age Group‐Specific Fracture Incidence Rates Trends for Type 1 and 2 Diabetes Mellitus |
| title_sort | sex and age group specific fracture incidence rates trends for type 1 and 2 diabetes mellitus |
| topic | FRACTURES INCIDENCE TRENDS TYPE 1 DIABETES MELLITUS TYPE 2 DIABETES MELLITUS |
| url | https://doi.org/10.1002/jbm4.10836 |
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