Chondroitin sulfate micro granules embedded with oligochitosan-calcium complexes for potential osteoporosis prevention
Calcium citrate (CaCi) and chondroitin sulfate (CS) were renovated as edible granules by spray-drying and polymer (Eudragit) coating to develop bone-protective product. The granules were reinforced functionally with oligochitosan (Och). Characterizations of IR, DSC and XRD concluded that Ca and Och...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622000548 |
| _version_ | 1798024231917715456 |
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| author | Lihua Chen Junsong Li Xiaolin Bi Jing Ji Lingchong Wang Jianming Cheng |
| author_facet | Lihua Chen Junsong Li Xiaolin Bi Jing Ji Lingchong Wang Jianming Cheng |
| author_sort | Lihua Chen |
| collection | DOAJ |
| description | Calcium citrate (CaCi) and chondroitin sulfate (CS) were renovated as edible granules by spray-drying and polymer (Eudragit) coating to develop bone-protective product. The granules were reinforced functionally with oligochitosan (Och). Characterizations of IR, DSC and XRD concluded that Ca and Och were concordantly incorporated into granules and embedded into the CS matrix. The Ca-loading CS granules achieved about 1.6% Ca loading and 25% of Ca recovery in encapsulation. CaCi and Och would chelate together during preparation of the granules. Eudragit coating enabled the granules smooth and compact, and resulted in slow Ca release in dissolution. In a 28-days of animal test, oral administration with Ca + Och/CS granules inhibited osteoporosis progression in OVX rats through increasing serum Ca/P and internal Ca retention, as well as enhancing bone density and major minerals. Therefore, the composite granules have some potential in sustaining bone health owing to its improvements in Ca protection and the multi-nutritious delivery. |
| first_indexed | 2024-04-11T17:59:04Z |
| format | Article |
| id | doaj.art-ccb769c08dad49a4a1c02fa418f4328e |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-11T17:59:04Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-ccb769c08dad49a4a1c02fa418f4328e2022-12-22T04:10:35ZengElsevierJournal of Functional Foods1756-46462022-03-0190104984Chondroitin sulfate micro granules embedded with oligochitosan-calcium complexes for potential osteoporosis preventionLihua Chen0Junsong Li1Xiaolin Bi2Jing Ji3Lingchong Wang4Jianming Cheng5Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330004, ChinaKey Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330004, China; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, ChinaSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, ChinaSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, ChinaKey Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330004, China; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China; Corresponding authors at: School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing City 210023, China.School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China; Corresponding authors at: School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing City 210023, China.Calcium citrate (CaCi) and chondroitin sulfate (CS) were renovated as edible granules by spray-drying and polymer (Eudragit) coating to develop bone-protective product. The granules were reinforced functionally with oligochitosan (Och). Characterizations of IR, DSC and XRD concluded that Ca and Och were concordantly incorporated into granules and embedded into the CS matrix. The Ca-loading CS granules achieved about 1.6% Ca loading and 25% of Ca recovery in encapsulation. CaCi and Och would chelate together during preparation of the granules. Eudragit coating enabled the granules smooth and compact, and resulted in slow Ca release in dissolution. In a 28-days of animal test, oral administration with Ca + Och/CS granules inhibited osteoporosis progression in OVX rats through increasing serum Ca/P and internal Ca retention, as well as enhancing bone density and major minerals. Therefore, the composite granules have some potential in sustaining bone health owing to its improvements in Ca protection and the multi-nutritious delivery.http://www.sciencedirect.com/science/article/pii/S1756464622000548Micro granulesChondroitin sulfateOligochitosanCalcium supplementarySpray-drying |
| spellingShingle | Lihua Chen Junsong Li Xiaolin Bi Jing Ji Lingchong Wang Jianming Cheng Chondroitin sulfate micro granules embedded with oligochitosan-calcium complexes for potential osteoporosis prevention Journal of Functional Foods Micro granules Chondroitin sulfate Oligochitosan Calcium supplementary Spray-drying |
| title | Chondroitin sulfate micro granules embedded with oligochitosan-calcium complexes for potential osteoporosis prevention |
| title_full | Chondroitin sulfate micro granules embedded with oligochitosan-calcium complexes for potential osteoporosis prevention |
| title_fullStr | Chondroitin sulfate micro granules embedded with oligochitosan-calcium complexes for potential osteoporosis prevention |
| title_full_unstemmed | Chondroitin sulfate micro granules embedded with oligochitosan-calcium complexes for potential osteoporosis prevention |
| title_short | Chondroitin sulfate micro granules embedded with oligochitosan-calcium complexes for potential osteoporosis prevention |
| title_sort | chondroitin sulfate micro granules embedded with oligochitosan calcium complexes for potential osteoporosis prevention |
| topic | Micro granules Chondroitin sulfate Oligochitosan Calcium supplementary Spray-drying |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622000548 |
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