Cellular immunodeficiency related to chronic dermatophytosis in a patient with Schistosoma mansoni infection: can schistosomiasis induce immunodeficiency?
Abstract: Here, we describe a case of hepatosplenic schistosomiasis that progressed to widespread persistent dermatophytosis. Significant T and B lymphocytopenia was confirmed. T-cell deficit is associated with increased susceptibility to fungal infections of skin and mucous membranes. The accumulat...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100141&lng=en&tlng=en |
| _version_ | 1811257653445263360 |
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| author | Maurício Domingues Ferreira Anna Cristina Collaniere Dalton Luís Bertolini Noac Chuffi Barros Dewton de Moraes Vasconcelos |
| author_facet | Maurício Domingues Ferreira Anna Cristina Collaniere Dalton Luís Bertolini Noac Chuffi Barros Dewton de Moraes Vasconcelos |
| author_sort | Maurício Domingues Ferreira |
| collection | DOAJ |
| description | Abstract: Here, we describe a case of hepatosplenic schistosomiasis that progressed to widespread persistent dermatophytosis. Significant T and B lymphocytopenia was confirmed. T-cell deficit is associated with increased susceptibility to fungal infections of skin and mucous membranes. The accumulation of a large amount of blood cells in the spleen could have played a crucial role in the development of lymphocytopenia in the present case. Alternatively, the schistosomiasis-induced increase in prostaglandin E2 levels could have inhibited the production of interferon-γ, a cytokine fundamental to fungal resistance. This case shows the potential of hepatosplenic schistosomiasis to impair the immune response. |
| first_indexed | 2024-04-12T18:00:46Z |
| format | Article |
| id | doaj.art-ccb8ccb73eda4fc093465cf665dc5a5b |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-12T18:00:46Z |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-ccb8ccb73eda4fc093465cf665dc5a5b2022-12-22T03:22:11ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-984950114114410.1590/0037-8682-0107-2016S0037-86822017000100141Cellular immunodeficiency related to chronic dermatophytosis in a patient with Schistosoma mansoni infection: can schistosomiasis induce immunodeficiency?Maurício Domingues FerreiraAnna Cristina CollaniereDalton Luís BertoliniNoac Chuffi BarrosDewton de Moraes VasconcelosAbstract: Here, we describe a case of hepatosplenic schistosomiasis that progressed to widespread persistent dermatophytosis. Significant T and B lymphocytopenia was confirmed. T-cell deficit is associated with increased susceptibility to fungal infections of skin and mucous membranes. The accumulation of a large amount of blood cells in the spleen could have played a crucial role in the development of lymphocytopenia in the present case. Alternatively, the schistosomiasis-induced increase in prostaglandin E2 levels could have inhibited the production of interferon-γ, a cytokine fundamental to fungal resistance. This case shows the potential of hepatosplenic schistosomiasis to impair the immune response.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100141&lng=en&tlng=enSchistosomiasisImmunodeficiencyChronic dermatophytosis |
| spellingShingle | Maurício Domingues Ferreira Anna Cristina Collaniere Dalton Luís Bertolini Noac Chuffi Barros Dewton de Moraes Vasconcelos Cellular immunodeficiency related to chronic dermatophytosis in a patient with Schistosoma mansoni infection: can schistosomiasis induce immunodeficiency? Revista da Sociedade Brasileira de Medicina Tropical Schistosomiasis Immunodeficiency Chronic dermatophytosis |
| title | Cellular immunodeficiency related to chronic dermatophytosis in a patient with Schistosoma mansoni infection: can schistosomiasis induce immunodeficiency? |
| title_full | Cellular immunodeficiency related to chronic dermatophytosis in a patient with Schistosoma mansoni infection: can schistosomiasis induce immunodeficiency? |
| title_fullStr | Cellular immunodeficiency related to chronic dermatophytosis in a patient with Schistosoma mansoni infection: can schistosomiasis induce immunodeficiency? |
| title_full_unstemmed | Cellular immunodeficiency related to chronic dermatophytosis in a patient with Schistosoma mansoni infection: can schistosomiasis induce immunodeficiency? |
| title_short | Cellular immunodeficiency related to chronic dermatophytosis in a patient with Schistosoma mansoni infection: can schistosomiasis induce immunodeficiency? |
| title_sort | cellular immunodeficiency related to chronic dermatophytosis in a patient with schistosoma mansoni infection can schistosomiasis induce immunodeficiency |
| topic | Schistosomiasis Immunodeficiency Chronic dermatophytosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100141&lng=en&tlng=en |
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