Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability

Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability

The fidelity of chromosome segregation in mitosis is safeguarded by the precise regulation of kinetochore microtubule (k-MT) attachment stability. Previously, we demonstrated that Cyclin A/Cdk1 destabilizes k-MT attachments to promote faithful chromosome segregation. Here, we use quantitative phosph...

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Bibliographic Details
Main Authors: Ana Maria G Dumitru, Scott F Rusin, Amber E M Clark, Arminja N Kettenbach, Duane A Compton
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-11-01
Series:eLife
Subjects:
mitosis
kinetochore
Plk1
microtubule
cyclin dependent kinase
Online Access:https://elifesciences.org/articles/29303

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