Sphingosine kinase 1 overexpression contributes to sunitinib resistance in clear cell renal cell carcinoma
Sphingosine kinase 1 (SphK1) is the major source of the bioactive lipid and GPCR agonist sphingosine 1-phosphate (S1P). Although alterations in SphK1 expression and activity have been detected in various human malignancies, its potential molecular mechanisms in the development and sunitinib resistan...
| Main Authors: | , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
Taylor & Francis Group
2018-12-01
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| 丛编: | OncoImmunology |
| 主题: | |
| 在线阅读: | http://dx.doi.org/10.1080/2162402X.2018.1502130 |