Indole Acetic Acid Exerts Anti-Depressive Effects on an Animal Model of Chronic Mild Stress

Indole Acetic Acid Exerts Anti-Depressive Effects on an Animal Model of Chronic Mild Stress

Indole acetic acid (IAA), an intestinal bacteria-derived tryptophan metabolite, has been detected at abnormal concentrations in the cerebrospinal fluid and urine of depressed individuals. The effects of such altered IAA concentrations on mood regulation are not known. A mouse model of unpredictable...

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Bibliographic Details
Main Authors:	Ying Chen, Peijun Tian, Zheng Wang, Ruili Pan, Kexin Shang, Gang Wang, Jianxin Zhao, Wei Chen
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Series:	Nutrients
Subjects:	indole acetic acid depression HPA axis serotonin gut microbiota indole derivative
Online Access:	https://www.mdpi.com/2072-6643/14/23/5019

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